Beta-1,4 N-acetylgalactosaminyltransferase 2 (EC 2.4.1.-) (Sd(a) beta-1,4-GalNAc transferase) (UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase)
1_MGSAG 6_ FSVGK 11_ FHVEV 16_ ASRGR 21_ ECVSG 26_ TPECG 31_ NRLGS 36_ AGFGA 41_ LCLEL 46_ RGADP 51_ AWGPF 56_ AAHGR 61_ SRRQG 66_ SRFLW 71_ LLKIL 76_ VIILV 81_ LGIVG 86_ FMFGS 91_ MFLQA 96_ VFSSP 101_ KPELP 106_ SPAPG 111_ VQKLK 116_ LLPEE 121_ RLRNL 126_ FSYDG 131_ IWLFP 136_ KNQCK 141_ CEANK 146_ EQGGY 151_ NFQDA 156_ YGQSD 161_ LPAVK 166_ ARRQA 171_ EFEHF 176_ QRREG 181_ LPRPL 186_ PLLVQ 191_ PNLPF 196_ GYPVH 201_ GVEVM 206_ PLHTV 211_ PIPGL 216_ QFEGP 221_ DAPVY 226_ EVTLT 231_ ASLGT 236_ LNTLA 241_ DVPDS 246_ VVQGR 251_ GQKQL 256_ IISTS 261_ DRKLL 266_ KFILQ 271_ HVTYT 276_ STGYQ 281_ HQKVD 286_ IVSLE 291_ SRSSV 296_ AKFPV 301_ TIRHP 306_ VIPKL 311_ YDPGP 316_ ERKLR 321_ NLVTI 326_ ATKTF 331_ LRPHK 336_ LMIML 341_ RSIRE 346_ YYPDL 351_ TVIVA 356_ DDSQK 361_ PLEIK 366_ DNHVE 371_ YYTMP 376_ FGKGW 381_ FAGRN 386_ LAISQ 391_ VTTKY 396_ VLWVD 401_ DDFLF 406_ NEETK 411_ IEVLV 416_ DVLEK 421_ TELDV 426_ VGGSV 431_ LGNVF 436_ QFKLL 441_ LEQSE 446_ NGACL 451_ HKRMG 456_ FFQPL 461_ DGFPS 466_ CVVTS 471_ GVVNF 476_ FLAHT 481_ ERLQR 486_ VGFDP 491_ RLQRV 496_ AHSEF 501_ FIDGL 506_ GTLLV 511_ GSCPE 516_ VIIGH 521_ QSRSP 526_ VVDSE 531_ LAALE 536_ KTYNT 541_ YRSNT 546_ LTRVQ 551_ FKLAL 556_ HYFKN 561_HLQCA
1: Beta-1,4 N-acetylgalactosaminyltransferase involved in the biosynthesis of Sd(a) histo-blood group antigen. Catalyzes the transfer of N-acetylgalactosamine (GalNAc) group in a beta-1,4-linkage from UDP-GalNAc to the galactose residue of NeuAcalpha2->3Gal-R to form Sd(a) glycan epitope GalNAcbeta1->4(NeuAcalpha2->3)Gal-R. The Sd(a) epitope is carried in O- and N-linked glycoproteins and glycolipids, including O-linked core 1 structures on GYPA/glycophorin, SLC4A1 and SLC29A1 in erythrocytes, N-linked glycans attached to the Tamm-Horsfall glycoprotein UMOD/uromodulin in renal fluids, O-linked core 3 glycans on mucins in colon and neolactosides in gastric mucosa (PubMed:12678917, PubMed:14688233, PubMed:16024623, PubMed:35409292). Confers protection against influenza A virus strains that attach to NeuAcalpha2->3-carrying host receptors. Modifies N-glycan chains on host receptors and prevents virus entry into cells (PubMed:28813663)