E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
1_MSGSR 6_ QAGSG 11_ SAGTS 16_ PGSSA 21_ ASSVT 26_ SASSS 31_ LSSSP 36_ SPPSV 41_ AVSAA 46_ ALVSG 51_ GVAQA 56_ AGSGG 61_ LGGPV 66_ RPVLV 71_ APAVS 76_ GSGGG 81_ AVSTG 86_ LSRHS 91_ CAARP 96_ SAGVG 101_ GSSSS 106_ LGSGS 111_ RKRPL 116_ LAPLC 121_ NGLIN 126_ SYEDK 131_ SNDFV 136_ CPICF 141_ DMIEE 146_ AYMTK 151_ CGHSF 156_ CYKCI 161_ HQSLE 166_ DNNRC 171_ PKCNY 176_ VVDNI 181_ DHLYP 186_ NFLVN 191_ ELILK 196_ QKQRF 201_ EEKRF 206_ KLDHS 211_ VSSTN 216_ GHRWQ 221_ IFQDW 226_ LGTDQ 231_ DNLDL 236_ ANVNL 241_ MLELL 246_ VQKKK 251_ QLEAE 256_ SHAAQ 261_ LQILM 266_ EFLKV 271_ ARRNK 276_ REQLE 281_ QIQKE 286_ LSVLE 291_ EDIKR 296_ VEEMS 301_ GLYSP 306_ VSEDS 311_ TVPQF 316_ EAPSP 321_ SHSSI 326_ IDSTE 331_ YSQPP 336_ GFSGS 341_ SQTKK 346_ QPWYN 351_ STLAS 356_ RRKRL 361_ TAHFE 366_ DLEQC 371_ YFSTR 376_ MSRIS 381_ DDSRT 386_ ASQLD 391_ EFQEC 396_ LSKFT 401_ RYNSV 406_ RPLAT 411_ LSYAS 416_ DLYNG 421_ SSIVS 426_ SIEFD 431_ RDCDY 436_ FAIAG 441_ VTKKI 446_ KVYEY 451_ DTVIQ 456_ DAVDI 461_ HYPEN 466_ EMTCN 471_ SKISC 476_ ISWSS 481_ YHKNL 486_ LASSD 491_ YEGTV 496_ ILWDG 501_ FTGQR 506_ SKVYQ 511_ EHEKR 516_ CWSVD 521_ FNLMD 526_ PKLLA 531_ SGSDD 536_ AKVKL 541_ WSTNL 546_ DNSVA 551_ SIEAK 556_ ANVCC 561_ VKFSP 566_ SSRYH 571_ LAFGC 576_ ADHCV 581_ HYYDL 586_ RNTKQ 591_ PIMVF 596_ KGHRK 601_ AVSYA 606_ KFVSG 611_ EEIVS 616_ ASTDS 621_ QLKLW 626_ NVGKP 631_ YCLRS 636_ FKGHI 641_ NEKNF 646_ VGLAS 651_ NGDYI 656_ ACGSE 661_ NNSLY 666_ LYYKG 671_ LSKTL 676_ LTFKF 681_ DTVKS 686_ VLDKD 691_ RKEDD 696_ TNEFV 701_ SAVCW 706_ RALPD 711_ GESNV 716_ LIAAN 721_ SQGTI 726_KVLEL
1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable)