THO complex subunit 2 (Tho2) (hTREX120)
1_MAAAA 6_ VVVPA 11_ EWIKN 16_ WEKSG 21_ RGEFL 26_ HLCRI 31_ LSENK 36_ SHDSS 41_ TYRDF 46_ QQALY 51_ ELSYH 56_ VIKGN 61_ LKHEQ 66_ ASNVL 71_ SDISE 76_ FREDM 81_ PSILA 86_ DVFCI 91_ LDIET 96_ NCLEE 101_ KSKRD 106_ YFTQL 111_ VLACL 116_ YLVSD 121_ TVLKE 126_ RLDPE 131_ TLESL 136_ GLIKQ 141_ SQQFN 146_ QKSVK 151_ IKTKL 156_ FYKQQ 161_ KFNLL 166_ REENE 171_ GYAKL 176_ IAELG 181_ QDLSG 186_ SITSD 191_ LILEN 196_ IKSLI 201_ GCFNL 206_ DPNRV 211_ LDVIL 216_ EVFEC 221_ RPEHD 226_ DFFIS 231_ LLESY 236_ MSMCE 241_ PQTLC 246_ HILGF 251_ KFKFY 256_ QEPNG 261_ ETPSS 266_ LYRVA 271_ AVLLQ 276_ FNLID 281_ LDDLY 286_ VHLLP 291_ ADNCI 296_ MDEHK 301_ REIAE 306_ AKQIV 311_ RKLTM 316_ VVLSS 321_ EKMDE 326_ REKEK 331_ EKEEE 336_ KVEKP 341_ PDNQK 346_ LGLLE 351_ ALLKI 356_ GDWQH 361_ AQNIM 366_ DQMPP 371_ YYAAS 376_ HKLIA 381_ LAICK 386_ LIHIT 391_ IEPLY 396_ RRVGV 401_ PKGAK 406_ GSPVN 411_ ALQNK 416_ RAPKQ 421_ AESFE 426_ DLRRD 431_ VFNMF 436_ CYLGP 441_ HLSHD 446_ PILFA 451_ KVVRI 456_ GKSFM 461_ KEFQS 466_ DGSKQ 471_ EDKEK 476_ TEVIL 481_ SCLLS 486_ ITDQV 491_ LLPSL 496_ SLMDC 501_ NACMS 506_ EELWG 511_ MFKTF 516_ PYQHR 521_ YRLYG 526_ QWKNE 531_ TYNSH 536_ PLLVK 541_ VKAQT 546_ IDRAK 551_ YIMKR 556_ LTKEN 561_ VKPSG 566_ RQIGK 571_ LSHSN 576_ PTILF 581_ DYILS 586_ QIQKY 591_ DNLIT 596_ PVVDS 601_ LKYLT 606_ SLNYD 611_ VLAYC 616_ IIEAL 621_ ANPEK 626_ ERMKH 631_ DDTTI 636_ SSWLQ 641_ SLASF 646_ CGAVF 651_ RKYPI 656_ DLAGL 661_ LQYVA 666_ NQLKA 671_ GKSFD 676_ LLILK 681_ EVVQK 686_ MAGIE 691_ ITEEM 696_ TMEQL 701_ EAMTG 706_ GEQLK 711_ AEGGY 716_ FGQIR 721_ NTKKS 726_ SQRLK 731_ DALLD 736_ HDLAL 741_ PLCLL 746_ MAQQR 751_ NGVIF 756_ QEGGE 761_ KHLKL 766_ VGKLY 771_ DQCHD 776_ TLVQF 781_ GGFLA 786_ SNLST 791_ EDYIK 796_ RVPSI 801_ DVLCN 806_ EFHTP 811_ HDAAF 816_ FLSRP 821_ MYAHH 826_ ISSKY 831_ DELKK 836_ SEKGS 841_ KQQHK 846_ VHKYI 851_ TSCEM 856_ VMAPV 861_ HEAVV 866_ SLHVS 871_ KVWDD 876_ ISPQF 881_ YATFW 886_ SLTMY 891_ DLAVP 896_ HTSYE 901_ REVNK 906_ LKVQM 911_ KAIDD 916_ NQEMP 921_ PNKKK 926_ KEKER 931_ CTALQ 936_ DKLLE 941_ EEKKQ 946_ MEHVQ 951_ RVLQR 956_ LKLEK 961_ DNWLL 966_ AKSTK 971_ NETIT 976_ KFLQL 981_ CIFPR 986_ CIFSA 991_ IDAVY 996_ CARFV 1001_ ELVHQ 1006_ QKTPN 1011_ FSTLL 1016_ CYDRV 1021_ FSDII 1026_ YTVAS 1031_ CTENE 1036_ ASRYG 1041_ RFLCC 1046_ MLETV 1051_ TRWHS 1056_ DRATY 1061_ EKECG 1066_ NYPGF 1071_ LTILR 1076_ ATGFD 1081_ GGNKA 1086_ DQLDY 1091_ ENFRH 1096_ VVHKW 1101_ HYKLT 1106_ KASVH 1111_ CLETG 1116_ EYTHI 1121_ RNILI 1126_ VLTKI 1131_ LPWYP 1136_ KVLNL 1141_ GQALE 1146_ RRVHK 1151_ ICQEE 1156_ KEKRP 1161_ DLYAL 1166_ AMGYS 1171_ GQLKS 1176_ RKSYM 1181_ IPENE 1186_ FHHKD 1191_ PPPRN 1196_ AVASV 1201_ QNGPG 1206_ GGPSS 1211_ SSIGS 1216_ ASKSD 1221_ ESSTE 1226_ ETDKS 1231_ RERSQ 1236_ CGVKA 1241_ VNKAS 1246_ STTPK 1251_ GNSSN 1256_ GNSGS 1261_ NSNKA 1266_ VKEND 1271_ KEKGK 1276_ EKEKE 1281_ KKEKT 1286_ PATTP 1291_ EARVL 1296_ GKDGK 1301_ EKPKE 1306_ ERPNK 1311_ DEKAR 1316_ ETKER 1321_ TPKSD 1326_ KEKEK 1331_ FKKEE 1336_ KAKDE 1341_ KFKTT 1346_ VPNAE 1351_ SKSTQ 1356_ ERERE 1361_ KEPSR 1366_ ERDIA 1371_ KEMKS 1376_ KENVK 1381_ GGEKT 1386_ PVSGS 1391_ LKSPV 1396_ PRSDI 1401_ PEPER 1406_ EQKRR 1411_ KIDTH 1416_ PSPSH 1421_ SSTVK 1426_ DSLIE 1431_ LKESS 1436_ AKLYI 1441_ NHTPP 1446_ PLSKS 1451_ KEREM 1456_ DKKDL 1461_ DKSRE 1466_ RSRER 1471_ EKKDE 1476_ KDRKE 1481_ RKRDH 1486_ SNNDR 1491_ EVPPD 1496_ LTKRR 1501_ KEENG 1506_ TMGVS 1511_ KHKSE 1516_ SPCES 1521_ PYPNE 1526_ KDKEK 1531_ NKSKS 1536_ SGKEK 1541_ GSDSF 1546_ KSEKM 1551_ DKISS 1556_ GGKKE 1561_ SRHDK 1566_ EKIEK 1571_ KEKRD 1576_ SSGGK 1581_ EEKKH 1586_HKSSD
1: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA and spliced mRNA (PubMed:23222130). The THOC1-THOC2-THOC3 core complex alone is sufficient to bind export factor NXF1-NXT1 and promote ATPase activity of DDX39B; in the complex THOC2 is the only component that directly interacts with DDX39B (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for NXF1 localization to the nuclear rim (PubMed:22893130). THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains
2: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production