Ly6/PLAUR domain-containing protein 6B
1_MLYKS 6_ SDRPA 11_ HKVSM 16_ LLLCH 21_ ALAIA 26_ VVQIV 31_ IFSES 36_ WAFAK 41_ NINFY 46_ NVRPP 51_ LDPTP 56_ FPNSF 61_ KCFTC 66_ ENAGD 71_ NYNCN 76_ RWAED 81_ KWCPQ 86_ NTQYC 91_ LTVHH 96_ FTSHG 101_ RSTSI 106_ TKKCA 111_ SRSEC 116_ HFVGC 121_ HHSRD 126_ SEHTE 131_ CRSCC 136_ EGMIC 141_ NVELP 146_ TNHTN 151_ AVFAV 156_ MHAQR 161_ TSGSS 166_ APTLY 171_ LPVLA 176_WVFVL
1: Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (PubMed:26586467, PubMed:34631692). In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner (PubMed:26586467). Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence (PubMed:26586467). However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs (PubMed:34631692)