Protein phosphatase PTC7 homolog (EC 3.1.3.16) (T-cell activation protein phosphatase 2C) (TA-PP2C) (T-cell activation protein phosphatase 2C-like)
1_MFSVL 6_ SYGRL 11_ VARAV 16_ LGGLS 21_ QTDPR 26_ AGGGG 31_ GGDYG 36_ LVTAG 41_ CGFGK 46_ DFRKG 51_ LLKKG 56_ ACYGD 61_ DACFV 66_ ARHRS 71_ ADVLG 76_ VADGV 81_ GGWRD 86_ YGVDP 91_ SQFSG 96_ TLMRT 101_ CERLV 106_ KEGRF 111_ VPSNP 116_ IGILT 121_ TSYCE 126_ LLQNK 131_ VPLLG 136_ SSTAC 141_ IVVLD 146_ RTSHR 151_ LHTAN 156_ LGDSG 161_ FLVVR 166_ GGEVV 171_ HRSDE 176_ QQHYF 181_ NTPFQ 186_ LSIAP 191_ PEAEG 196_ VVLSD 201_ SPDAA 206_ DSTSF 211_ DVQLG 216_ DIILT 221_ ATDGL 226_ FDNMP 231_ DYMIL 236_ QELKK 241_ LKNSN 246_ YESIQ 251_ QTARS 256_ IAEQA 261_ HELAY 266_ DPNYM 271_ SPFAQ 276_ FACDN 281_ GLNVR 286_ GGKPD 291_ DITVL 296_LSIVA
1: Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis (PubMed:30267671). Positively regulates biosynthesis of the ubiquinone, coenzyme Q (PubMed:30267671). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (PubMed:30267671). Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous (By similarity). May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability (By similarity). Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy (PubMed:38992176)