Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T)
1_MAATE 6_ ISVLS 11_ EQFTK 16_ IKELE 21_ LMPEK 26_ GLKEE 31_ EKDGV 36_ CREKD 41_ HRSPS 46_ ELEAE 51_ RTSGA 56_ FQDSV 61_ LEEEV 66_ ELVLA 71_ PSEES 76_ EKYIL 81_ TLQTV 86_ HFTSE 91_ AVELQ 96_ DMSLL 101_ SIQQQ 106_ EGVQV 111_ VVQQP 116_ GPGLL 121_ WLEEG 126_ PRQSL 131_ QQCVA 136_ ISIQQ 141_ ELYSP 146_ QEMEV 151_ LQFHA 156_ LEENV 161_ MVASE 166_ DSKLA 171_ VSLAE 176_ TTGLI 181_ KLEEE 186_ QEKNQ 191_ LLAER 196_ TKEQL 201_ FFVET 206_ MSGDE 211_ RSDEI 216_ VLTVS 221_ NSNVE 226_ EQEDQ 231_ PTAGQ 236_ ADAEK 241_ AKSTK 246_ NQRKT 251_ KGAKG 256_ TFHCD 261_ VCMFT 266_ SSRMS 271_ SFNRH 276_ MKTHT 281_ SEKPH 286_ LCHLC 291_ LKTFR 296_ TVTLL 301_ RNHVN 306_ THTGT 311_ RPYKC 316_ NDCNM 321_ AFVTS 326_ GELVR 331_ HRRYK 336_ HTHEK 341_ PFKCS 346_ MCKYA 351_ SVEAS 356_ KLKRH 361_ VRSHT 366_ GERPF 371_ QCCQC 376_ SYASR 381_ DTYKL 386_ KRHMR 391_ THSGE 396_ KPYEC 401_ HICHT 406_ RFTQS 411_ GTMKI 416_ HILQK 421_ HGENV 426_ PKYQC 431_ PHCAT 436_ IIARK 441_ SDLRV 446_ HMRNL 451_ HAYSA 456_ AELKC 461_ RYCSA 466_ VFHER 471_ YALIQ 476_ HQKTH 481_ KNEKR 486_ FKCKH 491_ CSYAC 496_ KQERH 501_ MTAHI 506_ RTHTG 511_ EKPFT 516_ CLSCN 521_ KCFRQ 526_ KQLLN 531_ AHFRK 536_ YHDAN 541_ FIPTV 546_ YKCSK 551_ CGKGF 556_ SRWIN 561_ LHRHS 566_ EKCGS 571_ GEAKS 576_ AASGK 581_ GRRTR 586_ KRKQT 591_ ILKEA 596_ TKGQK 601_ EAAKG 606_ WKEAA 611_ NGDEA 616_ AAEEA 621_ STTKG 626_ EQFPG 631_ EMFPV 636_ ACRET 641_ TARVK 646_ EEVDE 651_ GVTCE 656_MLLNT
1: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters