Proteasome subunit alpha-type 8 (Proteasome alpha 4 subunit) (Alpha4s) (Proteasome subunit alpha-type 7-like)
1_MASRY 6_ DRAIT 11_ VFSPD 16_ GHLFQ 21_ VEYAQ 26_ EAVKK 31_ GSTAV 36_ GIRGT 41_ NIVVL 46_ GVEKK 51_ SVAKL 56_ QDERT 61_ VRKIC 66_ ALDDH 71_ VCMAF 76_ AVLTI 81_ FIGLT 86_ ADARV 91_ VINRA 96_ RVECQ 101_ SHKLT 106_ VEDPV 111_ TVEYI 116_ TRFIA 121_ TLKQK 126_ YTQSN 131_ GRRPF 136_ GISAL 141_ IVGFD 146_ DDGIS 151_ RLYQT 156_ DPSGT 161_ YHAWK 166_ ANAIG 171_ RSAKT 176_ VREFL 181_ EKNYT 186_ EDAIA 191_ SDSEA 196_ IKLAI 201_ KALLE 206_ VVQSG 211_ GKNIE 216_ LAIIR 221_ RNQPL 226_ KMFSA 231_ KEVEL 236_ YVTEI 241_ EKEKE 246_ EAEKK 251_KSKKS
1: Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I