GrpE protein homolog 2, mitochondrial (Mt-GrpE#2)
1_MAVRS 6_ LWAGR 11_ LRVQR 16_ LLAWS 21_ AAWES 26_ KGWPL 31_ PFSTA 36_ TQRTA 41_ GEDCR 46_ SEDPP 51_ DELGP 56_ PLAER 61_ ALRVK 66_ AVKLE 71_ KEVQD 76_ LTVRY 81_ QRAIA 86_ DCENI 91_ RRRTQ 96_ RCVED 101_ AKIFG 106_ IQSFC 111_ KDLVE 116_ VADIL 121_ EKTTE 126_ CISEE 131_ SEPED 136_ QKLTL 141_ EKVFR 146_ GLLLL 151_ EAKLK 156_ SVFAK 161_ HGLEK 166_ LTPIG 171_ DKYDP 176_ HEHEL 181_ ICHVP 186_ AGVGV 191_ QPGTV 196_ ALVRQ 201_ DGYKL 206_ HGRTI 211_ RLARV 216_EVAVE
1: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity)