Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1)
1_MKAVK 6_ SERER 11_ GSRRR 16_ HRDGD 21_ VVLPA 26_ GVVVK 31_ QERLS 36_ PEVAP 41_ PAHRR 46_ PDHSG 51_ GSPSP 56_ PTSEP 61_ ARSGH 66_ RGNRA 71_ RGVSR 76_ SPPKK 81_ KNKAS 86_ GRRSK 91_ SPRSK 96_ RNRSP 101_ HHSTV 106_ KVKQE 111_ REDHP 116_ RRGRE 121_ DRQHR 126_ EPSEQ 131_ EHRRA 136_ RNSDR 141_ DRHRG 146_ HSHQR 151_ RTSNE 156_ RPGSG 161_ QGQGR 166_ DRDTQ 171_ NLQAQ 176_ EEERE 181_ FYNAR 186_ RREHR 191_ QRNDV 196_ GGGGS 201_ ESQEL 206_ VPRPG 211_ GNNKE 216_ KEVPA 221_ KEKPS 226_ FELSG 231_ ALLED 236_ TNTFR 241_ GVVIK 246_ YSEPP 251_ EARIP 256_ KKRWR 261_ LYPFK 266_ NDEVL 271_ PVMYI 276_ HRQSA 281_ YLLGR 286_ HRRIA 291_ DIPID 296_ HPSCS 301_ KQHAV 306_ FQYRL 311_ VEYTR 316_ ADGTV 321_ GRRVK 326_ PYIID 331_ LGSGN 336_ GTFLN 341_ NKRIE 346_ PQRYY 351_ ELKEK 356_ DVLKF 361_ GFSSR 366_ EYVLL 371_ HESSD 376_ TSEID 381_ RKDDE 386_ DEEEE 391_EEVSD
1: Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA