LHFPL tetraspan subfamily member 5 protein (Lipoma HMGIC fusion partner-like 5 protein) (Tetraspan membrane protein of hair cell stereocilia)
1_MVKLL 6_ PAQEA 11_ AKIYH 16_ TNYVR 21_ NSRAV 26_ GVMWG 31_ TLTIC 36_ FSVLV 41_ MALFI 46_ QPYWI 51_ GDSVN 56_ TPQAG 61_ YFGLF 66_ SYCVG 71_ NVLSS 76_ ELICK 81_ GGPLD 86_ FSSIP 91_ SRAFK 96_ TAMFF 101_ VALGM 106_ FLIIG 111_ SIICF 116_ SLFFI 121_ CNTAT 126_ VYKIC 131_ AWMQL 136_ AAATG 141_ LMIGC 146_ LVYPD 151_ GWDSS 156_ EVRRM 161_ CGEQT 166_ GKYTL 171_ GHCTI 176_ RWAFM 181_ LAILS 186_ IGDAL 191_ ILSFL 196_ AFVLG 201_ YRQDK 206_ LLPDD 211_YKADG
1: Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of the shorter stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. Functionally couples PCDH15 to the transduction channel