GTPase RhebL1 (Ras homolog enriched in brain like-1 c) (RhebL1c) (Ras homolog enriched in brain-like protein 1) (Rheb-like protein 1) (Rheb2)
1_MPLVR 6_ YRKVV 11_ ILGYR 16_ CVGKT 21_ SLAHQ 26_ FVEGE 31_ FSEGY 36_ DPTVE 41_ NTYSK 46_ IVTLG 51_ KDEFH 56_ LHLVD 61_ TAGQD 66_ EYSIL 71_ PYSFI 76_ IGVHG 81_ YVLVY 86_ SVTSL 91_ HSFQV 96_ IESLY 101_ QKLHE 106_ GHGKT 111_ RVPVV 116_ LVGNK 121_ ADLSP 126_ EREVQ 131_ AVEGK 136_ KLAES 141_ WGATF 146_ MESSA 151_ RENQL 156_ TQGIF 161_ TKVIQ 166_ EIARV 171_ ENSYG 176_QERRC
1: Binds GTP and exhibits intrinsic GTPase activity (By similarity). May activate NF-kappa-B-mediated gene transcription (PubMed:16328882). Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2