Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein)
1_MSSEM 6_ EPLLL 11_ AWSYF 16_ RRRKF 21_ QLCAD 26_ LCTQM 31_ LEKSP 36_ YDQEP 41_ DPELP 46_ VHQAA 51_ WILKA 56_ RALTE 61_ MVYID 66_ EIDVD 71_ QEGIA 76_ EMMLD 81_ ENAIA 86_ QVPRP 91_ GTSLK 96_ LPGTN 101_ QTGGP 106_ SQAVR 111_ PITQA 116_ GRPIT 121_ GFLRP 126_ STQSG 131_ RPGTM 136_ EQAIR 141_ TPRTA 146_ YTARP 151_ ITSSS 156_ GRFVR 161_ LGTAS 166_ MLTSP 171_ DGPFI 176_ NLSRL 181_ NLTKY 186_ SQKPK 191_ LAKAL 196_ FEYIF 201_ HHEND 206_ VKTIH 211_ LEDVV 216_ LHLGI 221_ YPFLL 226_ RNKNH 231_ IEKNA 236_ LDLAA 241_ LSTEH 246_ SQYKD 251_ WWWKV 256_ QIGKC 261_ YYRLG 266_ MYREA 271_ EKQFK 276_ SALKQ 281_ QEMVD 286_ TFLYL 291_ AKVYV 296_ SLDQP 301_ VTALN 306_ LFKQG 311_ LDKFP 316_ GEVTL 321_ LCGIA 326_ RIYEE 331_ MNNMS 336_ SAAEY 341_ YKEVL 346_ KQDNT 351_ HVEAI 356_ ACIGS 361_ NHFYS 366_ DQPEI 371_ ALRFY 376_ RRLLQ 381_ MGIYN 386_ GQLFN 391_ NLGLC 396_ CFYAQ 401_ QYDMT 406_ LTSFE 411_ RALSL 416_ AENEE 421_ EAADV 426_ WYNLG 431_ HVAVG 436_ IGDTN 441_ LAHQC 446_ FRLAL 451_ VNNNN 456_ HAEAY 461_ NNLAV 466_ LEMRK 471_ GHVEQ 476_ ARALL 481_ QTASS 486_ LAPHM 491_ YEPHF 496_ NFATI 501_ SDKIG 506_ DLQRS 511_ YVAAQ 516_ KSEAA 521_ FPDHV 526_ DTQHL 531_ IKQLR 536_QHFAM
1: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization