SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
1_MAVRK 6_ KDGGP 11_ NVKYY 16_ EAADT 21_ VTQFD 26_ NVRLW 31_ LGKNY 36_ KKYIQ 41_ AEPPT 46_ NKSLS 51_ SLVVQ 56_ LLQFQ 61_ EEVFG 66_ KHVSN 71_ APLTK 76_ LPIKC 81_ FLDFK 86_ AGGSL 91_ CHILA 96_ AAYKF 101_ KSDQG 106_ WRRYD 111_ FQNPS 116_ RMDRN 121_ VEMFM 126_ TIEKS 131_ LVQNN 136_ CLSRP 141_ NIFLC 146_ PEIEP 151_ KLLGK 156_ LKDII 161_ KRHQG 166_ TVTED 171_ KNNAS 176_ HVVYP 181_ VPGNL 186_ EEEEW 191_ VRPVM 196_ KRDKQ 201_ VLLHW 206_ GYYPD 211_ SYDTW 216_ IPASE 221_ IEASV 226_ EDAPT 231_ PEKPR 236_ KVHAK 241_ WILDT 246_ DTFNE 251_ WMNEE 256_ DYEVN 261_ DDKNP 266_ VSRRK 271_ KISAK 276_ TLTDE 281_ VNSPD 286_ SDRRD 291_ KKGGN 296_ YKKRK 301_ RSPSP 306_ SPTPE 311_ AKKKN 316_ AKKGP 321_ STPYT 326_ KSKRG 331_ HREEE 336_ QEDLT 341_ KDMDE 346_ PSPVP 351_ NVEEV 356_ TLPKT 361_ VNTKK 366_ DSESA 371_ PVKGG 376_ TMTDL 381_ DEQED 386_ ESMET 391_ TGKDE 396_ DENST 401_ GNKGE 406_ QTKNP 411_ DLHED 416_ NVTEQ 421_ THHII 426_ IPSYA 431_ AWFDY 436_ NSVHA 441_ IERRA 446_ LPEFF 451_ NGKNK 456_ SKTPE 461_ IYLAY 466_ RNFMI 471_ DTYRL 476_ NPQEY 481_ LTSTA 486_ CRRNL 491_ AGDVC 496_ AIMRV 501_ HAFLE 506_ QWGLI 511_ NYQVD 516_ AESRP 521_ TPMGP 526_ PPTSH 531_ FHVLA 536_ DTPSG 541_ LVPLQ 546_ PKTPQ 551_ QTSAS 556_ QQMLN 561_ FPDKG 566_ KEKPT 571_ DMQNF 576_ GLRTD 581_ MYTKK 586_ NVPSK 591_ SKAAA 596_ SATRE 601_ WTEQE 606_ TLLLL 611_ EALEM 616_ YKDDW 621_ NKVSE 626_ HVGSR 631_ TQDEC 636_ ILHFL 641_ RLPIE 646_ DPYLE 651_ DSEAS 656_ LGPLA 661_ YQPIP 666_ FSQSG 671_ NPVMS 676_ TVAFL 681_ ASVVD 686_ PRVAS 691_ AAAKS 696_ ALEEF 701_ SKMKE 706_ EVPTA 711_ LVEAH 716_ VRKVE 721_ EAAKV 726_ TGKAD 731_ PAFGL 736_ ESSGI 741_ AGTTS 746_ DEPER 751_ IEESG 756_ NDEAR 761_ VEGQA 766_ TDEKK 771_ EPKEP 776_ REGGG 781_ AIEEE 786_ AKEKT 791_ SEAPK 796_ KDEEK 801_ GKEGD 806_ SEKES 811_ EKSDG 816_ DPIVD 821_ PEKEK 826_ EPKEG 831_ QEEVL 836_ KEVVE 841_ SEGER 846_ KTKVE 851_ RDIGE 856_ GNLST 861_ AAAAA 866_ LAAAA 871_ VKAKH 876_ LAAVE 881_ ERKIK 886_ SLVAL 891_ LVETQ 896_ MKKLE 901_ IKLRH 906_ FEELE 911_ TIMDR 916_ EREAL 921_ EYQRQ 926_ QLLAD 931_ RQAFH 936_ MEQLK 941_ YAEMR 946_ ARQQH 951_ FQQMH 956_ QQQQQ 961_ PPPAL 966_ PPGSQ 971_ PIPPT 976_ GAAGP 981_ PAVHG 986_ LAVAP 991_ ASVVP 996_ APAGS 1001_ GAPPG 1006_ SLGPS 1011_ EQIGQ 1016_ AGSTA 1021_ GPQQQ 1026_ QPAGA 1031_ PQPGA 1036_ VPPGV 1041_ PPPGP 1046_ HGPSP 1051_ FPNQQ 1056_ TPPSM 1061_ MPGAV 1066_ PGSGH 1071_ PGVAG 1076_ NAPLG 1081_ LPFGM 1086_ PPPPP 1091_ PPAPS 1096_ IIPFG 1101_ SLADS 1106_ ISINL 1111_ PAPPN 1116_ LHGHH 1121_ HHLPF 1126_ APGTL 1131_ PPPNL 1136_ PVSMA 1141_ NPLHP 1146_ NLPAT 1151_ TTMPS 1156_ SLPLG 1161_ PGLGS 1166_ AAAQS 1171_ PAIVA 1176_ AVQGN 1181_ LLPSA 1186_ SPLPD 1191_ PGTPL 1196_ PPDPT 1201_ APSPG 1206_TVTPV
1: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:11018012). Can stimulate the ATPase activity of the catalytic subunit of these complexes (PubMed:10078207). May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells (PubMed:12192000). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (By similarity)