Nuclear protein localization protein 4 homolog (Protein NPL4)
1_MAESI 6_ IIRVQ 11_ SPDGV 16_ KRITA 21_ TKRET 26_ AATFL 31_ KKVAK 36_ EFGFQ 41_ NNGFS 46_ VYINR 51_ NKTGE 56_ ITASS 61_ NKSLN 66_ LLKIK 71_ HGDLL 76_ FLFPS 81_ SLAGP 86_ SSEME 91_ TSVPP 96_ GFKVF 101_ GAPNV 106_ VEDEI 111_ DQYLS 116_ KQDGK 121_ IYRSR 126_ DPQLC 131_ RHGPL 136_ GKCVH 141_ CVPLE 146_ PFDED 151_ YLNHL 156_ EPPVK 161_ HMSFH 166_ AYIRK 171_ LTGGA 176_ DKGKF 181_ VALEN 186_ ISCKI 191_ KSGCE 196_ GHLPW 201_ PNGIC 206_ TKCQP 211_ SAITL 216_ NRQKY 221_ RHVDN 226_ IMFEN 231_ HTVAD 236_ RFLDF 241_ WRKTG 246_ NQHFG 251_ YLYGR 256_ YTEHK 261_ DIPLG 266_ IRAEV 271_ AAIYE 276_ PPQIG 281_ TQNSL 286_ ELLED 291_ PKAEV 296_ VDEIA 301_ AKLGL 306_ RKVGW 311_ IFTDL 316_ VSEDT 321_ RKGTV 326_ RYSRN 331_ KDTYF 336_ LSSEE 341_ CITAG 346_ DFQNK 351_ HPNMC 356_ RLSPD 361_ GHFGS 366_ KFVTA 371_ VATGG 376_ PDNQV 381_ HFEGY 386_ QVSNQ 391_ CMALV 396_ RDECL 401_ LPCKD 406_ APELG 411_ YAKES 416_ SSEQY 421_ VPDVF 426_ YKDVD 431_ KFGNE 436_ ITQLA 441_ RPLPV 446_ EYLII 451_ DITTT 456_ FPKDP 461_ VYTFS 466_ ISQNP 471_ FPIEN 476_ RDVLG 481_ ETQDF 486_ HSLAT 491_ YLSQN 496_ TSSVF 501_ LDTIS 506_ DFHLL 511_ LFLVT 516_ NEVMP 521_ LQDSI 526_ SLLLE 531_ AVRTR 536_ NEELA 541_ QTWKR 546_ SEQWA 551_ TIEQL 556_ CSTVG 561_ GQLPG 566_ LHEYG 571_ AVGGS 576_ THTAT 581_ AAMWA 586_ CQHCT 591_ FMNQP 596_ GTGHC 601_EMCSL
1: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729)