Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1)
1_MALLL 6_ LLFLG 11_ LLGLW 16_ GLLCA 21_ CAQDP 26_ SPAAR 31_ WPPGP 36_ RPLPL 41_ VGNLH 46_ LLRLS 51_ QQDRS 56_ LMELS 61_ ERYGP 66_ VFTVH 71_ LGRQK 76_ TVVLT 81_ GFEAV 86_ KEALA 91_ GPGQE 96_ LADRP 101_ PIAIF 106_ QLIQR 111_ GGGIF 116_ FSSGA 121_ RWRAA 126_ RQFTV 131_ RALHS 136_ LGVGR 141_ EPVAD 146_ KILQE 151_ LKCLS 156_ GQLDG 161_ YRGRP 166_ FPLAL 171_ LGWAP 176_ SNITF 181_ ALLFG 186_ RRFDY 191_ RDPVF 196_ VSLLG 201_ LIDEV 206_ MVLLG 211_ SPGLQ 216_ LFNVY 221_ PWLGA 226_ LLQLH 231_ RPVLR 236_ KIEEV 241_ RAILR 246_ TLLEA 251_ RRPHV 256_ CPGDP 261_ VCSYV 266_ DALIQ 271_ QGQGD 276_ DPEGL 281_ FAEAN 286_ AVACT 291_ LDMVM 296_ AGTET 301_ TSATL 306_ QWAAL 311_ LMGRH 316_ PDVQG 321_ RVQEE 326_ LDRVL 331_ GPGRT 336_ PRLED 341_ QQALP 346_ YTSAV 351_ LHEVQ 356_ RFITL 361_ LPHVP 366_ RCTAA 371_ DTQLG 376_ GFLLP 381_ KGTPV 386_ IPLLT 391_ SVLLD 396_ ETQWQ 401_ TPGQF 406_ NPGHF 411_ LDANG 416_ HFVKR 421_ EAFLP 426_ FSAGR 431_ RVCVG 436_ ERLAR 441_ TELFL 446_ LFAGL 451_ LQRYR 456_ LLPPP 461_ GVSPA 466_ SLDTT 471_ PARAF 476_ TMRPR 481_AQALC
1: A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism (PubMed:22591743, PubMed:26936974). Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates (PubMed:26936974). Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs) (PubMed:22591743). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids (PubMed:22591743, PubMed:26936974). May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines (PubMed:16551781, PubMed:20805301, PubMed:24278521). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:22591743, PubMed:26936974)