(Lyso)-N-acylphosphatidylethanolamine lipase (EC 3.1.1.-) (Alpha/beta hydrolase domain-containing protein 4) (Abhydrolase domain-containing protein 4) (Alpha/beta-hydrolase 4)
1_MADDL 6_ EQQSQ 11_ GWLSS 16_ WLPTW 21_ RPTSM 26_ SQLKN 31_ VEARI 36_ LQCLQ 41_ NKFLA 46_ RYVSL 51_ PNQNK 56_ IWTVT 61_ VSPEQ 66_ NDRTP 71_ LVMVH 76_ GFGGG 81_ VGLWI 86_ LNMDS 91_ LSARR 96_ TLHTF 101_ DLLGF 106_ GRSSR 111_ PAFPR 116_ DPEGA 121_ EDEFV 126_ TSIET 131_ WRETM 136_ GIPSM 141_ ILLGH 146_ SLGGF 151_ LATSY 156_ SIKYP 161_ DRVKH 166_ LILVD 171_ PWGFP 176_ LRPTN 181_ PSEIR 186_ APPAW 191_ VKAVA 196_ SVLGR 201_ SNPLA 206_ VLRVA 211_ GPWGP 216_ GLVQR 221_ FRPDF 226_ KRKFA 231_ DFFED 236_ DTISE 241_ YIYHC 246_ NAQNP 251_ SGETA 256_ FKAMM 261_ ESFGW 266_ ARRPM 271_ LERIH 276_ LIRKD 281_ VPITM 286_ IYGSD 291_ TWIDT 296_ STGKK 301_ VKMQR 306_ PDSYV 311_ RDMEI 316_ KGASH 321_ HVYAD 326_ QPHIF 331_ NAVVE 336_EICDS
1: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine