Gene name: DEPTOR

Uniprot entry:

Q8TB45

Protein names:

DEP domain-containing mTOR-interacting protein (DEP domain-containing protein 6)

Protein sequence:

1_MEEGG 6_ STGSA 11_ GSDSS 16_ TSGSG 21_ GAQQR 26_ ELERM 31_ AEVLV 36_ TGEQL 41_ RLRLH 46_ EEKVI 51_ KDRRH 56_ HLKTY 61_ PNCFV 66_ AKELI 71_ DWLIE 76_ HKEAS 81_ DRETA 86_ IKLMQ 91_ KLADR 96_ GIIHH 101_ VCDEH 106_ KEFKD 111_ VKLFY 116_ RFRKD 121_ DGTFP 126_ LDNEV 131_ KAFMR 136_ GQRLY 141_ EKLMS 146_ PENTL 151_ LQPRE 156_ EEGVK 161_ YERTF 166_ MASEF 171_ LDWLV 176_ QEGEA 181_ TTRKE 186_ AEQLC 191_ HRLME 196_ HGIIQ 201_ HVSNK 206_ HPFVD 211_ SNLLY 216_ QFRMN 221_ FRRRR 226_ RLMEL 231_ LNEKS 236_ PSSQE 241_ THDSP 246_ FCLRK 251_ QSHDN 256_ RKSTS 261_ FMSVS 266_ PSKEI 271_ KIVSA 276_ VRRSS 281_ MSSCG 286_ SSGYF 291_ SSSPT 296_ LSSSP 301_ PVLCN 306_ PKSVL 311_ KRPVT 316_ SEELL 321_ TPGAP 326_ YARKT 331_ FTIVG 336_ DAVGW 341_ GFVVR 346_ GSKPC 351_ HIQAV 356_ DPSGP 361_ AAAAG 366_ MKVCQ 371_ FVVSV 376_ NGLNV 381_ LHVDY 386_ RTVSN 391_ LILTG 396_ PRTIV 401_MEVME

Protein annotations

Protein functions:

1: Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes (PubMed:19446321, PubMed:22017875, PubMed:22017876, PubMed:22017877, PubMed:25936805, PubMed:29382726, PubMed:34519268, PubMed:34519269). DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy (PubMed:22017875, PubMed:22017876, PubMed:22017877). In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity (PubMed:34519268, PubMed:34519269)