Proline-rich protein 7 (Synaptic proline-rich membrane protein)
1_MVMSQ 6_ GTYTF 11_ LTCFA 16_ GFWLI 21_ WGLIV 26_ LLCCF 31_ CSFLR 36_ RRLKR 41_ RQEER 46_ LREQN 51_ LRALE 56_ LEPLE 61_ LEGSL 66_ AGSPP 71_ GLAPP 76_ QPPPH 81_ RSRLE 86_ APAHA 91_ HSHPH 96_ VHVHP 101_ LLHHG 106_ PAQPH 111_ AHAHP 116_ HPHHH 121_ ALPHP 126_ PPTHL 131_ SVPPR 136_ PWSYP 141_ RQAES 146_ DMSKP 151_ PCYEE 156_ AVLMA 161_ EPPPP 166_ YSEVL 171_ TDTRG 176_ LYRKI 181_ VTPFL 186_ SRRDS 191_ AEKQE 196_ QPPPS 201_ YKPLF 206_ LDRGY 211_ TSALH 216_ LPSAP 221_ RPAPP 226_ CPALC 231_ LQADR 236_ GRRVF 241_ PSWTD 246_ SELSS 251_ REPLE 256_ HGAWR 261_ LPVSI 266_PLFGR
1: Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (PubMed:27458189). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:21460222). Might promote apoptosis in T cells (PubMed:21460222)