Pumilio homolog 2 (Pumilio-2)
1_MNHDF 6_ QALAL 11_ ESRGM 16_ GELLP 21_ TKKFW 26_ EPDDS 31_ TKDGQ 36_ KGIFL 41_ GDDEW 46_ RETAW 51_ GASHH 56_ SMSQP 61_ IMVQR 66_ RSGQG 71_ FHGNS 76_ EVNAI 81_ LSPRS 86_ ESGGL 91_ GVSMV 96_ EYVLS 101_ SSPAD 106_ KLDSR 111_ FRKGN 116_ FGTRD 121_ AETDG 126_ PEKGD 131_ QKGKA 136_ SPFEE 141_ DQNRD 146_ LKQGD 151_ DDDSK 156_ INGRG 161_ LPNGM 166_ DADCK 171_ DFNRT 176_ PGSRQ 181_ ASPTE 186_ VVERL 191_ GPNTN 196_ PSEGL 201_ GPLPN 206_ PTANK 211_ PLVEE 216_ FSNPE 221_ TQNLD 226_ AMEQV 231_ GLESL 236_ QFDYP 241_ GNQVP 246_ MDSSG 251_ ATVGL 256_ FDYNS 261_ QQQLF 266_ QRTNA 271_ LTVQQ 276_ LTAAQ 281_ QQQYA 286_ LAAAQ 291_ QPHIA 296_ GVFSA 301_ GLAPA 306_ AFVPN 311_ PYIIS 316_ AAPPG 321_ TDPYT 326_ AAGLA 331_ AAATL 336_ AGPAV 341_ VPPQY 346_ YGVPW 351_ GVYPA 356_ NLFQQ 361_ QAAAA 366_ ANNTA 371_ SQQAA 376_ SQAQP 381_ GQQQV 386_ LRAGA 391_ GQRPL 396_ TPNQG 401_ QQGQQ 406_ AESLA 411_ AAAAA 416_ NPTLA 421_ FGQGL 426_ ATGMP 431_ GYQVL 436_ APTAY 441_ YDQTG 446_ ALVVG 451_ PGART 456_ GLGAP 461_ VRLMA 466_ PTPVL 471_ ISSAA 476_ AQAAA 481_ AAAAG 486_ GTASS 491_ LTGST 496_ NGLFR 501_ PIGTQ 506_ PPQQQ 511_ QQQPS 516_ TNLQS 521_ NSFYG 526_ SSSLT 531_ NSSQS 536_ SSLFS 541_ HGPGQ 546_ PGSTS 551_ LGFGS 556_ GNSLG 561_ AAIGS 566_ ALSGF 571_ GSSVG 576_ SSASS 581_ SATRR 586_ ESLST 591_ SSDLY 596_ KRSSS 601_ SLAPI 606_ GQPFY 611_ NSLGF 616_ SSSPS 621_ PIGMP 626_ LPSQT 631_ PGHSL 636_ TPPPS 641_ LSSHG 646_ SSSSL 651_ HLGGL 656_ TNGSG 661_ RYISA 666_ APGAE 671_ AKYRS 676_ ASSTS 681_ SLFSS 686_ SSQLF 691_ PPSRL 696_ RYNRS 701_ DIMPS 706_ GRSRL 711_ LEDFR 716_ NNRFP 721_ NLQLR 726_ DLIGH 731_ IVEFS 736_ QDQHG 741_ SRFIQ 746_ QKLER 751_ ATPAE 756_ RQMVF 761_ NEILQ 766_ AAYQL 771_ MTDVF 776_ GNYVI 781_ QKFFE 786_ FGSLD 791_ QKLAL 796_ ATRIR 801_ GHVLP 806_ LALQM 811_ YGCRV 816_ IQKAL 821_ ESISS 826_ DQQVI 831_ SEMVK 836_ ELDGH 841_ VLKCV 846_ KDQNG 851_ NHVVQ 856_ KCIEC 861_ VQPQS 866_ LQFII 871_ DAFKG 876_ QVFVL 881_ STHPY 886_ GCRVI 891_ QRILE 896_ HCTAE 901_ QTLPI 906_ LEELH 911_ QHTEQ 916_ LVQDQ 921_ YGNYV 926_ IQHVL 931_ EHGRP 936_ EDKSK 941_ IVSEI 946_ RGKVL 951_ ALSQH 956_ KFASN 961_ VVEKC 966_ VTHAS 971_ RAERA 976_ LLIDE 981_ VCCQN 986_ DGPHS 991_ ALYTM 996_ MKDQY 1001_ ANYVV 1006_ QKMID 1011_ MAEPA 1016_ QRKII 1021_ MHKIR 1026_ PHITT 1031_ LRKYT 1036_ YGKHI 1041_ LAKLE 1046_ KYYLK 1051_ NSPDL 1056_ GPIGG 1061_PPNGM
1: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:22345517). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (PubMed:26724866). May regulate DCUN1D3 mRNA levels (PubMed:25349211). May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (PubMed:28431233)