3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (EC 4.1.3.4) (3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1) (HMGCL-like 1) (Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase) (er-cHL)
1_MGNVP 6_ SAVKH 11_ CLSYQ 16_ QLLRE 21_ HLWIG 26_ DSVAG 31_ ALDPA 36_ QTSLL 41_ TNLHC 46_ FQPDV 51_ SGFSV 56_ SLAGT 61_ VACIH 66_ WETSQ 71_ LSGLP 76_ EFVKI 81_ VEVGP 86_ RDGLQ 91_ NEKVI 96_ VPTDI 101_ KIEFI 106_ NRLSQ 111_ TGLSV 116_ IEVTS 121_ FVSSR 126_ WVPQM 131_ ADHTE 136_ VMKGI 141_ HQYPG 146_ VRYPV 151_ LTPNL 156_ QGFHH 161_ AVAAG 166_ ATEIS 171_ VFGAA 176_ SESFS 181_ KKNIN 186_ CSIEE 191_ SMGKF 196_ EEVVK 201_ SARHM 206_ NIPAR 211_ GYVSC 216_ ALGCP 221_ YEGSI 226_ TPQKV 231_ TEVSK 236_ RLYGM 241_ GCYEI 246_ SLGDT 251_ IGVGT 256_ PGSMK 261_ RMLES 266_ VMKEI 271_ PPGAL 276_ AVHCH 281_ DTYGQ 286_ ALANI 291_ LTALQ 296_ MGINV 301_ VDSAV 306_ SGLGG 311_ CPYAK 316_ GASGN 321_ VATED 326_ LIYML 331_ NGLGL 336_ NTGVN 341_ LYKVM 346_ EAGDF 351_ ICKAV 356_ NKTTN 361_SKVAQ
1: Non-mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues