E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
1_MNQPE 6_ SANDP 11_ EPLCA 16_ VCGQA 21_ HSLEE 26_ NHFYS 31_ YPEEV 36_ DDDLI 41_ CHICL 46_ QALLD 51_ PLDTP 56_ CGHTY 61_ CTLCL 66_ TNFLV 71_ EKDFC 76_ PMDRK 81_ PLVLQ 86_ HCKKS 91_ SILVN 96_ KLLNK 101_ LLVTC 106_ PFREH 111_ CTQVL 116_ QRCDL 121_ EHHFQ 126_ TSCKG 131_ ASHYG 136_ LTKDR 141_ KRRSQ 146_ DGCPD 151_ GCASL 156_ TATAP 161_ SPEVS 166_ AAATI 171_ SLMTD 176_ EPGLD 181_ NPAYV 186_ SSAED 191_ GQPAI 196_ SPVDS 201_ GRSNR 206_ TRARP 211_ FERST 216_ IRSRS 221_ FKKIN 226_ RALSV 231_ LRRTK 236_ SGSAV 241_ ANHAD 246_ QGREN 251_ SENTT 256_ APEVF 261_ PRLYH 266_ LIPDG 271_ EITSI 276_ KINRV 281_ DPSES 286_ LSIRL 291_ VGGSE 296_ TPLVH 301_ IIIQH 306_ IYRDG 311_ VIARD 316_ GRLLP 321_ GDIIL 326_ KVNGM 331_ DISNV 336_ PHNYA 341_ VRLLR 346_ QPCQV 351_ LWLTV 356_ MREQK 361_ FRSRN 366_ NGQAP 371_ DAYRP 376_ RDDSF 381_ HVILN 386_ KSSPE 391_ EQLGI 396_ KLVRK 401_ VDEPG 406_ VFIFN 411_ VLDGG 416_ VAYRH 421_ GQLEE 426_ NDRVL 431_ AINGH 436_ DLRYG 441_ SPESA 446_ AHLIQ 451_ ASERR 456_ VHLVV 461_ SRQVR 466_ QRSPD 471_ IFQEA 476_ GWNSN 481_ GSWSP 486_ GPGER 491_ SNTPK 496_ PLHPT 501_ ITCHE 506_ KVVNI 511_ QKDPG 516_ ESLGM 521_ TVAGG 526_ ASHRE 531_ WDLPI 536_ YVISV 541_ EPGGV 546_ ISRDG 551_ RIKTG 556_ DILLN 561_ VDGVE 566_ LTEVS 571_ RSEAV 576_ ALLKR 581_ TSSSI 586_ VLKAL 591_ EVKEY 596_ EPQED 601_ CSSPA 606_ ALDSN 611_ HNMAP 616_ PSDWS 621_ PSWVM 626_ WLELP 631_ RCLYN 636_ CKDIV 641_ LRRNT 646_ AGSLG 651_ FCIVG 656_ GYEEY 661_ NGNKP 666_ FFIKS 671_ IVEGT 676_ PAYND 681_ GRIRC 686_ GDILL 691_ AVNGR 696_ STSGM 701_ IHACL 706_ ARLLK 711_ ELKGR 716_ ITLTI 721_VSWPG
1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65
2: Isoform 2 provides an endocytic scaffold for IGSF5/JAM4