NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)
1_MADGE 6_ EPEKK 11_ RRRIE 16_ ELLAE 21_ KMAVD 26_ GGCGD 31_ TGDWE 36_ GRWNH 41_ VKKFL 46_ ERSGP 51_ FTHPD 56_ FEPST 61_ ESLQF 66_ LLDTC 71_ KVLVI 76_ GAGGL 81_ GCELL 86_ KNLAL 91_ SGFRQ 96_ IHVID 101_ MDTID 106_ VSNLN 111_ RQFLF 116_ RPKDI 121_ GRPKA 126_ EVAAE 131_ FLNDR 136_ VPNCN 141_ VVPHF 146_ NKIQD 151_ FNDTF 156_ YRQFH 161_ IIVCG 166_ LDSII 171_ ARRWI 176_ NGMLI 181_ SLLNY 186_ EDGVL 191_ DPSSI 196_ VPLID 201_ GGTEG 206_ FKGNA 211_ RVILP 216_ GMTAC 221_ IECTL 226_ ELYPP 231_ QVNFP 236_ MCTIA 241_ SMPRL 246_ PEHCI 251_ EYVRM 256_ LQWPK 261_ EQPFG 266_ EGVPL 271_ DGDDP 276_ EHIQW 281_ IFQKS 286_ LERAS 291_ QYNIR 296_ GVTYR 301_ LTQGV 306_ VKRII 311_ PAVAS 316_ TNAVI 321_ AAVCA 326_ TEVFK 331_ IATSA 336_ YIPLN 341_ NYLVF 346_ NDVDG 351_ LYTYT 356_ FEAER 361_ KENCP 366_ ACSQL 371_ PQNIQ 376_ FSPSA 381_ KLQEV 386_ LDYLT 391_ NSASL 396_ QMKSP 401_ AITAT 406_ LEGKN 411_ RTLYL 416_ QSVTS 421_ IEERT 426_ RPNLS 431_ KTLKE 436_ LGLVD 441_ GQELA 446_ VADVT 451_ TPQTV 456_LFKLH
1: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression