DnaJ homolog subfamily B member 14
1_MEGNR 6_ DEAEK 11_ CVEIA 16_ REALN 21_ AGNRE 26_ KAQRF 31_ LQKAE 36_ KLYPL 41_ PSARA 46_ LLEII 51_ MKNGS 56_ TAGNS 61_ PHCRK 66_ PSGSG 71_ DQSKP 76_ NCTKD 81_ STSGS 86_ GEGGK 91_ GYTKD 96_ QVDGV 101_ LSINK 106_ CKNYY 111_ EVLGV 116_ TKDAG 121_ DEDLK 126_ KAYRK 131_ LALKF 136_ HPDKN 141_ HAPGA 146_ TDAFK 151_ KIGNA 156_ YAVLS 161_ NPEKR 166_ KQYDL 171_ TGNEE 176_ QACNH 181_ QNNGR 186_ FNFHR 191_ GCEAD 196_ ITPED 201_ LFNIF 206_ FGGGF 211_ PSGSV 216_ HSFSN 221_ GRAGY 226_ SQQHQ 231_ HRHSG 236_ HEREE 241_ ERGDG 246_ GFSVF 251_ IQLMP 256_ IIVLI 261_ LVSLL 266_ SQLMV 271_ SNPPY 276_ SLYPR 281_ SGTGQ 286_ TIKMQ 291_ TENLG 296_ VVYYV 301_ NKDFK 306_ NEYKG 311_ MLLQK 316_ VEKSV 321_ EEDYV 326_ TNIRN 331_ NCWKE 336_ RQQKT 341_ DMQYA 346_ AKVYR 351_ DDRLR 356_ RKADA 361_ LSMDN 366_ CKELE 371_RLTSL
1: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912)
2: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:21673190, PubMed:24675744)