Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1)
1_MWSGP 6_ PQPDQ 11_ GLPPP 16_ LAAVP 21_ VPWKS 26_ TDPCQ 31_ GHRES 36_ PGALV 41_ ETSAG 46_ EEAQG 51_ QEGPA 56_ AAQLD 61_ VLRLR 66_ SSSME 71_ IREKG 76_ SEFLK 81_ EELHR 86_ AQKEL 91_ KLKDE 96_ ECERL 101_ SKVRE 106_ QLEQE 111_ LEELT 116_ ASLFE 121_ EAHKM 126_ VREAN 131_ MKQAA 136_ SEKQL 141_ KEARG 146_ KIDML 151_ QAEVT 156_ ALKTL 161_ VITST 166_ PASPN 171_ RELHP 176_ QLLSP 181_ TKAGP 186_ RKGHS 191_ RHKST 196_ SSTLC 201_ PAVCP 206_ AAGHT 211_ LTPDR 216_ EGKEV 221_ DTILF 226_ AEFQA 231_ WRESP 236_ TLDKT 241_ CPFLE 246_ RVYRE 251_ DVGPC 256_ LDFTM 261_ QELSV 266_ LVRAA 271_ VEDNT 276_ LTIEP 281_ VASQT 286_ LPTVK 291_ VAEVD 296_ CSSTN 301_ TCALS 306_ GLTRT 311_ CRHRI 316_ RLGDS 321_ KSHYY 326_ ISPSS 331_ RARIT 336_ AVCNF 341_ FTYIR 346_ YIQQG 351_ LVRQD 356_ AEPMF 361_ WEIMR 366_ LRKEM 371_ SLAKL 376_GFFPQ
1: Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B