Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)
1_MASSS 6_ VPPAT 11_ VSAAT 16_ AGPGP 21_ GFGFA 26_ SKTKK 31_ KHFVQ 36_ QKVKV 41_ FRAAD 46_ PLVGV 51_ FLWGV 56_ AHSIN 61_ ELSQV 66_ PPPVM 71_ LLPDD 76_ FKASS 81_ KIKVN 86_ NHLFH 91_ RENLP 96_ SHFKF 101_ KEYCP 106_ QVFRN 111_ LRDRF 116_ GIDDQ 121_ DYLVS 126_ LTRNP 131_ PSESE 136_ GSDGR 141_ FLISY 146_ DRTLV 151_ IKEVS 156_ SEDIA 161_ DMHSN 166_ LSNYH 171_ QYIVK 176_ CHGNT 181_ LLPQF 186_ LGMYR 191_ VSVDN 196_ EDSYM 201_ LVMRN 206_ MFSHR 211_ LPVHR 216_ KYDLK 221_ GSLVS 226_ REASD 231_ KEKVK 236_ ELPTL 241_ KDMDF 246_ LNKNQ 251_ KVYIG 256_ EEEKK 261_ IFLEK 266_ LKRDV 271_ EFLVQ 276_ LKIMD 281_ YSLLL 286_ GIHDI 291_ IRGSE 296_ PEEEA 301_ PVRED 306_ ESEVD 311_ GDCSL 316_ TGPPA 321_ LVGSY 326_ GTSPE 331_ GIGGY 336_ IHSHR 341_ PLGPG 346_ EFESF 351_ IDVYA 356_ IRSAE 361_ GAPQK 366_ EVYFM 371_ GLIDI 376_ LTQYD 381_ AKKKA 386_ AHAAK 391_ TVKHG 396_ AGAEI 401_ STVHP 406_ EQYAK 411_ RFLDF 416_ITNIF
1: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439)