Gene name: RBM46

Uniprot entry:

Q8TBY0

Protein names:

Probable RNA-binding protein 46 (Cancer/testis antigen 68) (CT68) (RNA-binding motif protein 46)

Protein sequence:

1_MNEEN 6_ IDGTN 11_ GCSKV 16_ RTGIQ 21_ NEAAL 26_ LALME 31_ KTGYN 36_ MVQEN 41_ GQRKF 46_ GGPPP 51_ GWEGP 56_ PPPRG 61_ CEVFV 66_ GKIPR 71_ DMYED 76_ ELVPV 81_ FERAG 86_ KIYEF 91_ RLMME 96_ FSGEN 101_ RGYAF 106_ VMYTT 111_ KEEAQ 116_ LAIRI 121_ LNNYE 126_ IRPGK 131_ FIGVC 136_ VSLDN 141_ CRLFI 146_ GAIPK 151_ EKKKE 156_ EILDE 161_ MKKVT 166_ EGVVD 171_ VIVYP 176_ SATDK 181_ TKNRG 186_ FAFVE 191_ YESHR 196_ AAAMA 201_ RRKLI 206_ PGTFQ 211_ LWGHT 216_ IQVDW 221_ ADPEK 226_ EVDEE 231_ TMQRV 236_ KVLYV 241_ RNLMI 246_ STTEE 251_ TIKAE 256_ FNKFK 261_ PGAVE 266_ RVKKL 271_ RDYAF 276_ VHFFN 281_ REDAV 286_ AAMSV 291_ MNGKC 296_ IDGAS 301_ IEVTL 306_ AKPVN 311_ KENTW 316_ RQHLN 321_ GQISP 326_ NSENL 331_ IVFAN 336_ KEESH 341_ PKTLG 346_ KLPTL 351_ PARLN 356_ GQHSP 361_ SPPEV 366_ ERCTY 371_ PFYPG 376_ TKLTP 381_ ISMYS 386_ LKSNH 391_ FNSAV 396_ MHLDY 401_ YCNKN 406_ NWAPP 411_ EYYLY 416_ STTSQ 421_ DGKVL 426_ LVYKI 431_ VIPAI 436_ ANGSQ 441_ SYFMP 446_ DKLCT 451_ TLEDA 456_ KELAA 461_ QFTLL 466_ HLDYN 471_ FHRSS 476_ INSLS 481_ PVSAT 486_ LSSGT 491_ PSVLP 496_ YTSRP 501_ YSYPG 506_ YPLSP 511_ TISLA 516_ NGSHV 521_ GQRLC 526_ISNQA

Protein annotations

Protein functions:

1: Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I (By similarity). Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry (By similarity). Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation (By similarity). Required for spermatogonial differentiation in both developing and adult testis (By similarity)