Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)
1_MVELM 6_ FPLLL 11_ LLLPF 16_ LLYMA 21_ APQIR 26_ KMLSS 31_ GVCTS 36_ TVQLP 41_ GKVVV 46_ VTGAN 51_ TGIGK 56_ ETAKE 61_ LAQRG 66_ ARVYL 71_ ACRDV 76_ EKGEL 81_ VAKEI 86_ QTTTG 91_ NQQVL 96_ VRKLD 101_ LSDTK 106_ SIRAF 111_ AKGFL 116_ AEEKH 121_ LHVLI 126_ NNAGV 131_ MMCPY 136_ SKTAD 141_ GFEMH 146_ IGVNH 151_ LGHFL 156_ LTHLL 161_ LEKLK 166_ ESAPS 171_ RIVNV 176_ SSLAH 181_ HLGRI 186_ HFHNL 191_ QGEKF 196_ YNAGL 201_ AYCHS 206_ KLANI 211_ LFTQE 216_ LARRL 221_ KGSGV 226_ TTYSV 231_ HPGTV 236_ QSELV 241_ RHSSF 246_ MRWMW 251_ WLFSF 256_ FIKTP 261_ QQGAQ 266_ TSLHC 271_ ALTEG 276_ LEILS 281_ GNHFS 286_ DCHVA 291_ WVSAQ 296_ ARNET 301_ IARRL 306_ WDVSC 311_DLLGL
1: Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12036956, PubMed:12226107, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12036956, PubMed:12226107)