Gene name: TMEM163

Uniprot entry:

Q8TC26

Protein names:

Transmembrane protein 163

Protein sequence:

1_MEPAA 6_ GIQRR 11_ SSQGP 16_ TVPPP 21_ PRGHA 26_ PPAAA 31_ PGPAP 36_ LSSPV 41_ REPPQ 46_ LEEER 51_ QVRIS 56_ ESGQF 61_ SDGLE 66_ DRGLL 71_ ESSTR 76_ LKPHE 81_ AQNYR 86_ KKALW 91_ VSWFS 96_ IIVTL 101_ ALAVA 106_ AFTVS 111_ VMRYS 116_ ASAFG 121_ FAFDA 126_ ILDVL 131_ SSAIV 136_ LWRYS 141_ NAAAV 146_ HSAHR 151_ EYIAC 156_ VILGV 161_ IFLLS 166_ SICIV 171_ VKAIH 176_ DLSTR 181_ LLPEV 186_ DDFLF 191_ SVSIL 196_ SGILC 201_ SILAV 206_ LKFML 211_ GKVLT 216_ SRALI 221_ TDGFN 226_ SLVGG 231_ VMGFS 236_ ILLSA 241_ EVFKH 246_ DSAVW 251_ YLDGS 256_ IGVLI 261_ GLTIF 266_ AYGVK 271_ LLIDM 276_ VPRVR 281_QTRHY

Protein annotations

Protein functions:

1: Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (PubMed:32492420). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (PubMed:35455965)