E3 ubiquitin-protein ligase RNF217 (EC 2.3.2.31) (IBR domain-containing protein 1) (Opposite STL) (RING finger protein 217)
1_MGEEQ 6_ STVSG 11_ GGGPQ 16_ ESQTL 21_ ASGTA 26_ GHPEP 31_ PRPQG 36_ DSARA 41_ PPLRA 46_ ASAEP 51_ SGGGC 56_ GSDWG 61_ CADTS 66_ APEPA 71_ RSLGP 76_ PGWSK 81_ SRAPA 86_ QPAGL 91_ ALTGP 96_ LNPQT 101_ LPLQL 106_ ELEEE 111_ EEEAG 116_ DRKEG 121_ GDEQQ 126_ EAPPG 131_ EELEP 136_ RTRVG 141_ AADGL 146_ VLDVL 151_ GQRRP 156_ SLAKR 161_ QVFCS 166_ VYCVE 171_ SDLPE 176_ APASE 181_ QLSPP 186_ ASPPG 191_ APPVL 196_ NPPST 201_ RSSFP 206_ SPRLS 211_ LPTDS 216_ LSPDG 221_ GSIEL 226_ EFYLA 231_ PEPFS 236_ MPSLL 241_ GAPPY 246_ SGLGG 251_ VGDPY 256_ VPLMV 261_ LMCRV 266_ CLEDK 271_ PIKPL 276_ PCCKK 281_ AVCEE 286_ CLKVY 291_ LSAQV 296_ QLGQV 301_ EIKCP 306_ ITECF 311_ EFLEE 316_ TTVVY 321_ NLTHE 326_ DSIKY 331_ KYFLE 336_ LGRID 341_ SSTKP 346_ CPQCK 351_ HFTTF 356_ KKKGH 361_ IPTPS 366_ RSESK 371_ YKIQC 376_ PTCQF 381_ VWCFK 386_ CHSPW 391_ HEGVN 396_ CKEYK 401_ KGDKL 406_ LRHWA 411_ SEIEH 416_ GQRNA 421_ QKCPK 426_ CKIHI 431_ QRTEG 436_ CDHMT 441_ CSQCN 446_ TNFCY 451_ RCGER 456_ YRQLR 461_ FFGDH 466_ TSNLS 471_ IFGCK 476_ YRYLP 481_ ERPHL 486_ RRLVR 491_ GSVCA 496_ GKLFI 501_ APLIM 506_ VLGLA 511_ LGAIA 516_ VVIGL 521_ FVFPI 526_ YCLCK 531_ KQRKR 536_SRTGM
1: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis