Piwi-like protein 2 (EC 3.1.26.-) (Cancer/testis antigen 80) (CT80)
1_MDPFR 6_ PSFRG 11_ QSPIH 16_ PSQCQ 21_ AVRMP 26_ GCWPQ 31_ ASKPL 36_ DPALG 41_ RGAPA 46_ GRGHV 51_ FGKPE 56_ EPSTQ 61_ RGPAQ 66_ RESVG 71_ LVSMF 76_ RGLGI 81_ ETVSK 86_ TPLKR 91_ EMLPS 96_ GRGIL 101_ GRGLS 106_ ANLVR 111_ KDREE 116_ LSPTF 121_ WDPKV 126_ LAAGD 131_ SKMAE 136_ TSVGW 141_ SRTLG 146_ RGSSD 151_ ASLLP 156_ LGRAA 161_ GGISR 166_ EVDKP 171_ PCTFS 176_ TPSRG 181_ PPQLS 186_ SPPAL 191_ PQSPL 196_ HSPDR 201_ PLVLT 206_ VEHKE 211_ KELIV 216_ KQGSK 221_ GTPQS 226_ LGLNL 231_ VKIQC 236_ HNEAV 241_ YQYHV 246_ TFSPN 251_ VECKS 256_ MRFGM 261_ LKDHQ 266_ AVTGN 271_ VTAFD 276_ GSILY 281_ LPVKL 286_ QQVLE 291_ LKSQR 296_ KTDSA 301_ EISIK 306_ IQMTK 311_ ILEPC 316_ SDLCI 321_ PFYNV 326_ VFRRV 331_ MKLLD 336_ MKLVG 341_ RNFYD 346_ PTSAM 351_ VLQQH 356_ RLQIW 361_ PGYAA 366_ SIRRT 371_ DGGLF 376_ LLADV 381_ SHKVI 386_ RNDCV 391_ LDVMH 396_ AIYQQ 401_ NKEHF 406_ QDECT 411_ KLLVG 416_ NIVIT 421_ RYNNR 426_ TYRID 431_ DVDWN 436_ KTPKD 441_ SFTMS 446_ DGKEI 451_ TFLEY 456_ YSKNY 461_ GITVK 466_ EEDQP 471_ LLIHR 476_ PSERQ 481_ DNHGM 486_ LLKGE 491_ ILLLP 496_ ELSFM 501_ TGIPE 506_ KMKKD 511_ FRAMK 516_ DLAQQ 521_ INLSP 526_ KQHHS 531_ ALECL 536_ LQRIA 541_ KNEAA 546_ TNELM 551_ RWGLR 556_ LQKDV 561_ HKIEG 566_ RVLPM 571_ ERINL 576_ KNTSF 581_ ITSQE 586_ LNWVK 591_ EVTRD 596_ PSILT 601_ IPMHF 606_ WALFY 611_ PKRAM 616_ DQARE 621_ LVNML 626_ EKIAG 631_ PIGMR 636_ MSPPA 641_ WVELK 646_ DDRIE 651_ TYVRT 656_ IQSTL 661_ GAEGK 666_ IQMVV 671_ CIIMG 676_ PRDDL 681_ YGAIK 686_ KLCCV 691_ QSPVP 696_ SQVVN 701_ VRTIG 706_ QPTRL 711_ RSVAQ 716_ KILLQ 721_ INCKL 726_ GGELW 731_ GVDIP 736_ LKQLM 741_ VIGMD 746_ VYHDP 751_ SRGMR 756_ SVVGF 761_ VASIN 766_ LTLTK 771_ WYSRV 776_ VFQMP 781_ HQEIV 786_ DSLKL 791_ CLVGS 796_ LKKFY 801_ EVNHC 806_ LPEKI 811_ VVYRD 816_ GVSDG 821_ QLKTV 826_ ANYEI 831_ PQLQK 836_ CFEAF 841_ ENYQP 846_ KMVVF 851_ VVQKK 856_ ISTNL 861_ YLAAP 866_ QNFVT 871_ PTPGT 876_ VVDHT 881_ ITSCE 886_ WVDFY 891_ LLAHH 896_ VRQGC 901_ GIPTH 906_ YVCVL 911_ NTANL 916_ SPDHM 921_ QRLTF 926_ KLCHM 931_ YWNWP 936_ GTIRV 941_ PAPCK 946_ YAHKL 951_ AFLSG 956_ HILHH 961_ EPAIQ 966_LCENL
1: Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660). Represses circadian rhythms by promoting the stability and activity of core clock components BMAL1 and CLOCK by inhibiting GSK3B-mediated phosphorylation and ubiquitination-dependent degradation of these proteins (PubMed:28903391)