Mitochondria-eating protein (Spermatogenesis-associated protein 18)
1_MAENL 6_ KRLVS 11_ NETLR 16_ TLQEK 21_ LDFWL 26_ KEYNT 31_ NTCDQ 36_ NLNHC 41_ LELIE 46_ QVAKV 51_ QGQLF 56_ GILTA 61_ AAQEG 66_ GRNDG 71_ VETIK 76_ SRLLP 81_ WLEAS 86_ FTAAS 91_ LGKSV 96_ DSKVP 101_ SLQDT 106_ FDRER 111_ HKDPS 116_ PRDRD 121_ MQQLD 126_ SNLNS 131_ TRSQC 136_ NQVQD 141_ DLVET 146_ EKNLE 151_ ESKNR 156_ SAISL 161_ LAAEE 166_ EINQL 171_ KKQLK 176_ SLQAQ 181_ EDARH 186_ RNTDQ 191_ RSSEN 196_ RRSEP 201_ WSLEE 206_ RKREQ 211_ WNSLK 216_ QNADQ 221_ QDTEA 226_ MSDYK 231_ KQLRN 236_ LKEEI 241_ AVLSA 246_ EKSAL 251_ QGRSS 256_ RSRSP 261_ SPAPR 266_ SRSCS 271_ RSRSA 276_ SPSTA 281_ VKVRR 286_ PSPNR 291_ SKLSN 296_ VARKA 301_ ALLSR 306_ FSDSY 311_ SQARL 316_ DAQCL 321_ LRRCI 326_ DKAET 331_ VQRII 336_ YIATV 341_ EAFHV 346_ AKMAF 351_ RHFKI 356_ HVRKS 361_ LTPSY 366_ VGSND 371_ FENAV 376_ LDYVI 381_ CHLDL 386_ YDSQS 391_ SVNDV 396_ IRAMN 401_ VNPKI 406_ SFPPV 411_ VDFCL 416_ LSDFI 421_ QEICC 426_ IAFAM 431_ QALEP 436_ PLDIA 441_ YGADG 446_ EVFND 451_ CKYRR 456_ SYDSD 461_ FTAPL 466_ VLYHV 471_ WPALM 476_ ENDCV 481_ IMKGE 486_ AVTRR 491_ GAFWN 496_ SVRSV 501_ SRCRS 506_ RSLSP 511_ ICPRS 516_ QIGLN 521_ TMSRS 526_ RSPSP 531_IRCGL
1: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage (PubMed:21264221, PubMed:21264228, PubMed:22292033, PubMed:22532927). Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen (PubMed:21264221, PubMed:21264228, PubMed:22292033, PubMed:22532927). Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes (PubMed:21264228). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (PubMed:22292033). Binds cardiolipin (PubMed:38322995). May form molecular condensates (non-membrane-bounded organelles) within mitochondria that compartmentalize and promote cardiolipin metabolism (PubMed:38322995)