Gene name: METTL6

Uniprot entry:

Q8TCB7

Protein names:

tRNA N(3)-methylcytidine methyltransferase METTL6 (EC 2.1.1.-) (Methyltransferase-like protein 6) (hMETTL6)

Protein sequence:

1_MASLQ 6_ RKGLQ 11_ ARILT 16_ SEEEE 21_ KLKRD 26_ QTLVS 31_ DFKQQ 36_ KLEQE 41_ AQKNW 46_ DLFYK 51_ RNSTN 56_ FFKDR 61_ HWTTR 66_ EFEEL 71_ RSCRE 76_ FEDQK 81_ LTMLE 86_ AGCGV 91_ GNCLF 96_ PLLEE 101_ DPNIF 106_ AYACD 111_ FSPRA 116_ IEYVK 121_ QNPLY 126_ DTERC 131_ KVFQC 136_ DLTKD 141_ DLLDH 146_ VPPES 151_ VDVVM 156_ LIFVL 161_ SAVHP 166_ DKMHL 171_ VLQNI 176_ YKVLK 181_ PGKSV 186_ LFRDY 191_ GLYDH 196_ AMLRF 201_ KASSK 206_ LGENF 211_ YVRQD 216_ GTRSY 221_ FFTDD 226_ FLAQL 231_ FMDTG 236_ YEEVV 241_ NEYVF 246_ RETVN 251_ KKEGL 256_ CVPRV 261_ FLQSK 266_ FLKPP 271_ KNPSP 276_VVLGL

Protein annotations

Protein functions:

1: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34268557, PubMed:34862464, PubMed:34922197). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation (PubMed:34268557)