Solute carrier family 22 member 8 (Organic anion transporter 3) (hOAT3)
1_MTFSE 6_ ILDRV 11_ GSMGH 16_ FQFLH 21_ VAILG 26_ LPILN 31_ MANHN 36_ LLQIF 41_ TAATP 46_ VHHCR 51_ PPHNA 56_ STGPW 61_ VLPMG 66_ PNGKP 71_ ERCLR 76_ FVHPP 81_ NASLP 86_ NDTQR 91_ AMEPC 96_ LDGWV 101_ YNSTK 106_ DSIVT 111_ EWDLV 116_ CNSNK 121_ LKEMA 126_ QSIFM 131_ AGILI 136_ GGLVL 141_ GDLSD 146_ RFGRR 151_ PILTC 156_ SYLLL 161_ AASGS 166_ GAAFS 171_ PTFPI 176_ YMVFR 181_ FLCGF 186_ GISGI 191_ TLSTV 196_ ILNVE 201_ WVPTR 206_ MRAIM 211_ STALG 216_ YCYTF 221_ GQFIL 226_ PGLAY 231_ AIPQW 236_ RWLQL 241_ TVSIP 246_ FFVFF 251_ LSSWW 256_ TPESI 261_ RWLVL 266_ SGKSS 271_ KALKI 276_ LRRVA 281_ VFNGK 286_ KEEGE 291_ RLSLE 296_ ELKLN 301_ LQKEI 306_ SLAKA 311_ KYTAS 316_ DLFRI 321_ PMLRR 326_ MTFCL 331_ SLAWF 336_ ATGFA 341_ YYSLA 346_ MGVEE 351_ FGVNL 356_ YILQI 361_ IFGGV 366_ DVPAK 371_ FITIL 376_ SLSYL 381_ GRHTT 386_ QAAAL 391_ LLAGG 396_ AILAL 401_ TFVPL 406_ DLQTV 411_ RTVLA 416_ VFGKG 421_ CLSSS 426_ FSCLF 431_ LYTSE 436_ LYPTV 441_ IRQTG 446_ MGVSN 451_ LWTRV 456_ GSMVS 461_ PLVKI 466_ TGEVQ 471_ PFIPN 476_ IIYGI 481_ TALLG 486_ GSAAL 491_ FLPET 496_ LNQPL 501_ PETIE 506_ DLENW 511_ SLRAK 516_ KPKQE 521_ PEVEK 526_ ASQRI 531_ PLQPH 536_GPGLG
1: Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (PubMed:14586168, PubMed:15644426, PubMed:15846473, PubMed:16455804, PubMed:31553721). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:14586168, PubMed:15846473, PubMed:15864504, PubMed:22108572, PubMed:23832370). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:11306713, PubMed:14586168, PubMed:15846473). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (PubMed:26377792). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule (PubMed:11907186). Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate (PubMed:22108572, PubMed:23832370). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside (PubMed:15644426). May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (PubMed:11669456, PubMed:15846473, PubMed:16455804). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (PubMed:14675047). May contribute to the release of cortisol in the adrenals (PubMed:15864504). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (By similarity)