Gene name: DENND10

Uniprot entry:

Q8TCE6

Protein names:

DENN domain-containing protein 10 (Protein FAM45A)

Protein sequence:

1_MAAAE 6_ VADTQ 11_ LMLGV 16_ GLIEK 21_ DTNGE 26_ VLWVW 31_ CYPST 36_ TATLR 41_ NLLLR 46_ KCCLT 51_ DENKL 56_ LHPFV 61_ FGQYR 66_ RTWFY 71_ ITTIE 76_ VPDSS 81_ ILKKV 86_ THFSI 91_ VLTAK 96_ DFNPE 101_ KYAAF 106_ TRILC 111_ RMYLK 116_ HGSPV 121_ KMMES 126_ YIAVL 131_ TKGIC 136_ QSEEN 141_ GSFLS 146_ KDFDA 151_ RKAYL 156_ AGSIK 161_ DIVSQ 166_ FGMET 171_ VILHT 176_ ALMLK 181_ KRIVV 186_ YHPKI 191_ EAVQE 196_ FTRTL 201_ PALVW 206_ HRQDW 211_ TILHS 216_ YVHLN 221_ ADELE 226_ ALQMC 231_ TGYVA 236_ GFVDL 241_ EVSNR 246_ PDLYD 251_ VFVNL 256_ AESEI 261_ TIAPL 266_ AKEAM 271_ AMGKL 276_ HKEMG 281_ QLIVQ 286_ SAEDP 291_ EKSES 296_ HVIQD 301_ IALKT 306_ REIFT 311_ NLAPF 316_ SEVSA 321_ DGEKR 326_ VLNLE 331_ ALKQK 336_ RFPPA 341_ TENFL 346_ YHLAA 351_AEQML

Protein annotations

Protein functions:

1: Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B (PubMed:38459129). Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form (PubMed:30771381, PubMed:38459129)