AN1-type zinc finger protein 1 (Zinc finger AN1-type-containing protein 1)
1_MAELD 6_ IGQHC 11_ QVEHC 16_ RQRDF 21_ LPFVC 26_ DDCSG 31_ IFCLE 36_ HRSRE 41_ SHGCP 46_ EVTVI 51_ NERLK 56_ TDQHT 61_ SYPCS 66_ FKDCA 71_ ERELV 76_ AVICP 81_ YCEKN 86_ FCLRH 91_ RHQSD 96_ HECEK 101_ LEIPK 106_ PRMAA 111_ TQKLV 116_ KDIID 121_ SKTGE 126_ TASKR 131_ WKGAK 136_ NSETA 141_ AKVAL 146_ MKLKM 151_ HADGD 156_ KSLPQ 161_ TERIY 166_ FQVFL 171_ PKGSK 176_ EKSKP 181_ MFFCH 186_ RWSIG 191_ KAIDF 196_ AASLA 201_ RLKND 206_ NNKFT 211_ AKKLR 216_ LCHIT 221_ SGEAL 226_ PLDHT 231_ LETWI 236_ AKEDC 241_ PLYNG 246_ GNIIL 251_ EYLND 256_ EEQFC 261_KNVES
1: Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830)