Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen)
1_MDSTA 6_ CLKSL 11_ LLTVS 16_ QYKAV 21_ KSEAN 26_ ATQLL 31_ RHLEV 36_ ISGQK 41_ LTRLF 46_ TSNQI 51_ LTSEC 56_ LSCLV 61_ ELLED 66_ PNISA 71_ SLILS 76_ IIGLL 81_ SQLAV 86_ DIETR 91_ DCLQN 96_ TYNLN 101_ SVLAG 106_ VVCRS 111_ SHTDS 116_ VFLQC 121_ IQLLQ 126_ KLTYN 131_ VKIFY 136_ SGANI 141_ DELIT 146_ FLIDH 151_ IQSSE 156_ DELKM 161_ PCLGL 166_ LANLC 171_ RHNLS 176_ VQTHI 181_ KTLSN 186_ VKSFY 191_ RTLIT 196_ LLAHS 201_ SLTVV 206_ VFALS 211_ ILSSL 216_ TLNEE 221_ VGEKL 226_ FHARN 231_ IHQTF 236_ QLIFN 241_ ILING 246_ DGTLT 251_ RKYSV 256_ DLLMD 261_ LLKNP 266_ KIADY 271_ LTRYE 276_ HFSSC 281_ LHQVL 286_ GLLNG 291_ KDPDS 296_ SSKVL 301_ ELLLA 306_ FCSVT 311_ QLRHM 316_ LTQMM 321_ FEQSP 326_ PGSAT 331_ LGSHT 336_ KCLEP 341_ TVALL 346_ RWLSQ 351_ PLDGS 356_ ENCSV 361_ LALEL 366_ FKEIF 371_ EDVID 376_ AANCS 381_ SADRF 386_ VTLLL 391_ PTILD 396_ QLQFT 401_ EQNLD 406_ EALTR 411_ KKCER 416_ IAKAI 421_ EVLLT 426_ LCGDD 431_ TLKMH 436_ IAKIL 441_ TTVKC 446_ TTLIE 451_ QQFTY 456_ GKIDL 461_ GFGTK 466_ VADSE 471_ LCKLA 476_ ADVIL 481_ KTLDL 486_ INKLK 491_ PLVPG 496_ MEVSF 501_ YKILQ 506_ DPRLI 511_ TPLAF 516_ ALTSD 521_ NREQV 526_ QSGLR 531_ ILLEA 536_ APLPD 541_ FPALV 546_ LGESI 551_ AANNA 556_ YRQQE 561_ TEHIP 566_ RKMPW 571_ QSSNH 576_ SFPTS 581_ IKCLT 586_ PHLKD 591_ GVPGL 596_ NIEEL 601_ IEKLQ 606_ SGMVV 611_ KDQIC 616_ DVRIS 621_ DIMDV 626_ YEMKL 631_ STLAS 636_ KESRL 641_ QDLLE 646_ TKALA 651_ LAQAD 656_ RLIAQ 661_ HRCQR 666_ TQAET 671_ EARTL 676_ ASMLR 681_ EVERK 686_ NEELS 691_ VLLKA 696_ QQVES 701_ ERAQS 706_ DIEHL 711_ FQHNR 716_ KLESV 721_ AEEHE 726_ ILTKS 731_ YMELL 736_ QRNES 741_ TEKKN 746_ KDLQI 751_ TCDSL 756_ NKQIE 761_ TVKKL 766_ NESLK 771_ EQNEK 776_ SIAQL 781_ IEKEE 786_ QRKEV 791_ QNQLV 796_ DREHK 801_ LANLH 806_ QKTKV 811_ QEEKI 816_ KTLQK 821_ EREDK 826_ EETID 831_ ILRKE 836_ LSRTE 841_ QIRKE 846_ LSIKA 851_ SSLEV 856_ QKAQL 861_ EGRLE 866_ EKESL 871_ VKLQQ 876_ EELNK 881_ HSHMI 886_ AMIHS 891_ LSGGK 896_INPET
1: Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668)