Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA)
1_MEDPS 6_ EPDRL 11_ ASADG 16_ GSPEE 21_ EEDGE 26_ REPLL 31_ PRIAW 36_ AHPRR 41_ GAPGS 46_ AVRLL 51_ DAAGE 56_ EGEAG 61_ DEELP 66_ LPPGD 71_ VGVSR 76_ SSSAE 81_ LDRSR 86_ PAVSV 91_ TIGTS 96_ EMNAF 101_ LDDPE 106_ FADIM 111_ LRAEQ 116_ AIEVG 121_ IFPER 126_ ISQGS 131_ SGSYF 136_ VKDPK 141_ RKIIG 146_ VFKPK 151_ SEEPY 156_ GQLNP 161_ KWTKY 166_ VHKVC 171_ CPCCF 176_ GRGCL 181_ IPNQG 186_ YLSEA 191_ GAYLV 196_ DNKLH 201_ LSIVP 206_ KTKVV 211_ WLVSE 216_ TFNYN 221_ AIDRA 226_ KSRGK 231_ KYALE 236_ KVPKV 241_ GRKFH 246_ RIGLP 251_ PKIGS 256_ FQLFV 261_ EGYKE 266_ AEYWL 271_ RKFEA 276_ DPLPE 281_ NIRKQ 286_ FQSQF 291_ ERLVI 296_ LDYII 301_ RNTDR 306_ GNDNW 311_ LVRYE 316_ KQKCE 321_ KEIDH 326_ KESKW 331_ IDDEE 336_ FLIKI 341_ AAIDN 346_ GLAFP 351_ FKHPD 356_ EWRAY 361_ PFHWA 366_ WLPQA 371_ KVPFS 376_ EEIRN 381_ LILPY 386_ ISDMN 391_ FVQDL 396_ CEDLY 401_ ELFKT 406_ DKGFD 411_ KATFE 416_ SQMSV 421_ MRGQI 426_ LNLTQ 431_ ALRDG 436_ KSPFQ 441_ LVQIP 446_ CVIVE 451_ RSQGG 456_ SQGRI 461_ VHLSN 466_ SFTQT 471_ VNCRK 476_PFFSS
1: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell (PubMed:11923287, PubMed:12324459). This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments (PubMed:11923287, PubMed:12324459). The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (PubMed:11923287, PubMed:12324459). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking