Carnitine O-palmitoyltransferase 1, brain isoform (CPT1-B) (EC 2.3.1.21) (CPT IC) (Carnitine O-palmitoyltransferase I, brain isoform) (CPTI-B) (Carnitine palmitoyltransferase 1C)
1_MAEAH 6_ QAVGF 11_ RPSLT 16_ SDGAE 21_ VELSA 26_ PVLQE 31_ IYLSG 36_ LRSWK 41_ RHLSR 46_ FWNDF 51_ LTGVF 56_ PASPL 61_ SWLFL 66_ FSAIQ 71_ LAWFL 76_ QLDPS 81_ LGLME 86_ KIKEL 91_ LPDWG 96_ GQHHG 101_ LRGVL 106_ AAALF 111_ ASCLW 116_ GALIF 121_ TLHVA 126_ LRLLL 131_ SYHGW 136_ LLEPH 141_ GAMSS 146_ PTKTW 151_ LALVR 156_ IFSGR 161_ HPMLF 166_ SYQRS 171_ LPRQP 176_ VPSVQ 181_ DTVRK 186_ YLESV 191_ RPILS 196_ DEDFD 201_ WTAVL 206_ AQEFL 211_ RLQAS 216_ LLQWY 221_ LRLKS 226_ WWASN 231_ YVSDW 236_ WEEFV 241_ YLRSR 246_ NPLMV 251_ NSNYY 256_ MMDFL 261_ YVTPT 266_ PLQAA 271_ RAGNA 276_ VHALL 281_ LYRHR 286_ LNRQE 291_ IPPTL 296_ LMGMR 301_ PLCSA 306_ QYEKI 311_ FNTTR 316_ IPGVQ 321_ KDYIR 326_ HLHDS 331_ QHVAV 336_ FHRGR 341_ FFRMG 346_ THSRN 351_ SLLSP 356_ RALEQ 361_ QFQRI 366_ LDDPS 371_ PACPH 376_ EEHLA 381_ ALTAA 386_ PRGTW 391_ AQVRT 396_ SLKTQ 401_ AAEAL 406_ EAVEG 411_ AAFFV 416_ SLDAE 421_ PAGLT 426_ REDPA 431_ ASLDA 436_ YAHAL 441_ LAGRG 446_ HDRWF 451_ DKSFT 456_ LIVFS 461_ NGKLG 466_ LSVEH 471_ SWADC 476_ PISGH 481_ MWEFT 486_ LATEC 491_ FQLGY 496_ STDGH 501_ CKGHP 506_ DPTLP 511_ QPQRL 516_ QWDLP 521_ DQIHS 526_ SISLA 531_ LRGAK 536_ ILSEN 541_ VDCHV 546_ VPFSL 551_ FGKSF 556_ IRRCH 561_ LSSDS 566_ FIQIA 571_ LQLAH 576_ FRDRG 581_ QFCLT 586_ YESAM 591_ TRLFL 596_ EGRTE 601_ TVRSC 606_ TREAC 611_ NFVRA 616_ MEDKE 621_ KTDPQ 626_ CLALF 631_ RVAVD 636_ KHQAL 641_ LKAAM 646_ SGQGV 651_ DRHLF 656_ ALYIV 661_ SRFLH 666_ LQSPF 671_ LTQVH 676_ SEQWQ 681_ LSTSQ 686_ IPVQQ 691_ MHLFD 696_ VHNYP 701_ DYVSS 706_ GGGFG 711_ PADDH 716_ GYGVS 721_ YIFMG 726_ DGMIT 731_ FHISS 736_ KKSST 741_ KTDSH 746_ RLGQH 751_ IEDAL 756_ LDVAS 761_ LFQAG 766_ QHFKR 771_ RFRGS 776_ GKENS 781_ RHRCG 786_ FLSRQ 791_ TGASK 796_ASMTS
1: Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1 (PubMed:30135643). Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner (By similarity). Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control (PubMed:16651524). Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels (PubMed:25751282, PubMed:30135643)