E3 ubiquitin-protein ligase MARCHF1 (EC 2.3.2.27) (Membrane-associated RING finger protein 1) (Membrane-associated RING-CH protein I) (MARCH-I) (RING finger protein 171) (RING-type E3 ubiquitin transferase MARCHF1)
1_MLGWC 6_ EAIAR 11_ NPHRI 16_ PNNTR 21_ TPEIS 26_ GDLAD 31_ ASQTS 36_ TLNEK 41_ SPGRS 46_ ASRSS 51_ NISKA 56_ SSPTT 61_ GTAPR 66_ SQSRL 71_ SVCPS 76_ TQDIC 81_ RICHC 86_ EGDEE 91_ SPLIT 96_ PCRCT 101_ GTLRF 106_ VHQSC 111_ LHQWI 116_ KSSDT 121_ RCCEL 126_ CKYDF 131_ IMETK 136_ LKPLR 141_ KWEKL 146_ QMTTS 151_ ERRKI 156_ FCSVT 161_ FHVIA 166_ ITCVV 171_ WSLYV 176_ LIDRT 181_ AEEIK 186_ QGNDN 191_ GVLEW 196_ PFWTK 201_ LVVVA 206_ IGFTG 211_ GLVFM 216_ YVQCK 221_ VYVQL 226_ WRRLK 231_ AYNRV 236_ IFVQN 241_ CPDTA 246_ KKLEK 251_ NFSCN 256_ VNTDI 261_ KDAVV 266_ VPVPQ 271_ TGANS 276_ LPSAE 281_GGPPE
1: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:18389477, PubMed:18305173, PubMed:21220452, PubMed:35045264). By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Also regulates insulin sensitivity by controlling surface expression of the insulin receptor subunit beta/INSR by direct ubiquitination and degradation (PubMed:27577745)
2: (Microbial infection) Plays a role in iron metabolism by regulating the levels of the transferrin receptor TFRC during human cytomegalovirus infection, subsequently contributing to a proviral effect