Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) (3'-5' RNA exonuclease OLD35) (PNPase old-35) (Polynucleotide phosphorylase 1) (PNPase 1) (Polynucleotide phosphorylase-like protein)
1_MAACR 6_ YCCSC 11_ LRLRP 16_ LSDGP 21_ FLLPR 26_ RDRAL 31_ TQLQV 36_ RALWS 41_ SAGSR 46_ AVAVD 51_ LGNRK 56_ LEISS 61_ GKLAR 66_ FADGS 71_ AVVQS 76_ GDTAV 81_ MVTAV 86_ SKTKP 91_ SPSQF 96_ MPLVV 101_ DYRQK 106_ AAAAG 111_ RIPTN 116_ YLRRE 121_ IGTSD 126_ KEILT 131_ SRIID 136_ RSIRP 141_ LFPAG 146_ YFYDT 151_ QVLCN 156_ LLAVD 161_ GVNEP 166_ DVLAI 171_ NGASV 176_ ALSLS 181_ DIPWN 186_ GPVGA 191_ VRIGI 196_ IDGEY 201_ VVNPT 206_ RKEMS 211_ SSTLN 216_ LVVAG 221_ APKSQ 226_ IVMLE 231_ ASAEN 236_ ILQQD 241_ FCHAI 246_ KVGVK 251_ YTQQI 256_ IQGIQ 261_ QLVKE 266_ TGVTK 271_ RTPQK 276_ LFTPS 281_ PEIVK 286_ YTHKL 291_ AMERL 296_ YAVFT 301_ DYEHD 306_ KVSRD 311_ EAVNK 316_ IRLDT 321_ EEQLK 326_ EKFPE 331_ ADPYE 336_ IIESF 341_ NVVAK 346_ EVFRS 351_ IVLNE 356_ YKRCD 361_ GRDLT 366_ SLRNV 371_ SCEVD 376_ MFKTL 381_ HGSAL 386_ FQRGQ 391_ TQVLC 396_ TVTFD 401_ SLESG 406_ IKSDQ 411_ VITAI 416_ NGIKD 421_ KNFML 426_ HYEFP 431_ PYATN 436_ EIGKV 441_ TGLNR 446_ RELGH 451_ GALAE 456_ KALYP 461_ VIPRD 466_ FPFTI 471_ RVTSE 476_ VLESN 481_ GSSSM 486_ ASACG 491_ GSLAL 496_ MDSGV 501_ PISSA 506_ VAGVA 511_ IGLVT 516_ KTDPE 521_ KGEIE 526_ DYRLL 531_ TDILG 536_ IEDYN 541_ GDMDF 546_ KIAGT 551_ NKGIT 556_ ALQAD 561_ IKLPG 566_ IPIKI 571_ VMEAI 576_ QQASV 581_ AKKEI 586_ LQIMN 591_ KTISK 596_ PRASR 601_ KENGP 606_ VVETV 611_ QVPLS 616_ KRAKF 621_ VGPGG 626_ YNLKK 631_ LQAET 636_ GVTIS 641_ QVDEE 646_ TFSVF 651_ APTPS 656_ AMHEA 661_ RDFIT 666_ EICKD 671_ DQEQQ 676_ LEFGA 681_ VYTAT 686_ ITEIR 691_ DTGVM 696_ VKLYP 701_ NMTAV 706_ LLHNT 711_ QLDQR 716_ KIKHP 721_ TALGL 726_ EVGQE 731_ IQVKY 736_ FGRDP 741_ ADGRM 746_ RLSRK 751_ VLQSP 756_ ATTVV 761_ RTLND 766_ RSSIV 771_ MGEPI 776_SQSSS
1: RNA-binding protein implicated in numerous RNA metabolic processes (PubMed:29967381, PubMed:39019044). Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction (PubMed:29967381, PubMed:39019044). Mitochondrial intermembrane factor with RNA-processing exoribonulease activity (PubMed:29967381, PubMed:39019044). Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner (PubMed:29967381, PubMed:39019044). Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381, PubMed:39019044). Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA