Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4)
1_MGATG 6_ AAEPL 11_ QSVLW 16_ VKQQR 21_ CAVSL 26_ EPARA 31_ LLRWW 36_ RSPGP 41_ GAGAP 46_ GADAC 51_ SVPVS 56_ EIIAV 61_ EETDV 66_ HGKHQ 71_ GSGKW 76_ QKMEK 81_ PYAFT 86_ VHCVK 91_ RARRH 96_ RWKWA 101_ QVTFW 106_ CPEEQ 111_ LCHLW 116_ LQTLR 121_ EMLEK 126_ LTSRP 131_ KHLLV 136_ FINPF 141_ GGKGQ 146_ GKRIY 151_ ERKVA 156_ PLFTL 161_ ASITT 166_ DIIVT 171_ EHANQ 176_ AKETL 181_ YEINI 186_ DKYDG 191_ IVCVG 196_ GDGMF 201_ SEVLH 206_ GLIGR 211_ TQRSA 216_ GVDQN 221_ HPRAV 226_ LVPSS 231_ LRIGI 236_ IPAGS 241_ TDCVC 246_ YSTVG 251_ TSDAE 256_ TSALH 261_ IVVGD 266_ SLAMD 271_ VSSVH 276_ HNSTL 281_ LRYSV 286_ SLLGY 291_ GFYGD 296_ IIKDS 301_ EKKRW 306_ LGLAR 311_ YDFSG 316_ LKTFL 321_ SHHCY 326_ EGTVS 331_ FLPAQ 336_ HTVGS 341_ PRDRK 346_ PCRAG 351_ CFVCR 356_ QSKQQ 361_ LEEEQ 366_ KKALY 371_ GLEAA 376_ EDVEE 381_ WQVVC 386_ GKFLA 391_ INATN 396_ MSCAC 401_ RRSPR 406_ GLSPA 411_ AHLGD 416_ GSSDL 421_ ILIRK 426_ CSRFN 431_ FLRFL 436_ IRHTN 441_ QQDQF 446_ DFTFV 451_ EVYRV 456_ KKFQF 461_ TSKHM 466_ EDEDS 471_ DLKEG 476_ GKKRF 481_ GHICS 486_ SHPSC 491_ CCTVS 496_ NSSWN 501_ CDGEV 506_ LHSPA 511_ IEVRV 516_ HCQLV 521_ RLFAR 526_ GIEEN 531_PKPDS
1: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031)