Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)
1_MAEQT 6_ YSWAY 11_ SLVDS 16_ SQVST 21_ FLISI 26_ LLIVY 31_ GSFRS 36_ LNMDF 41_ ENQDK 46_ EKDSN 51_ SSSGS 56_ FNGNS 61_ TNNSI 66_ QTIDS 71_ TQALF 76_ LPIGA 81_ SVSLL 86_ VMFFF 91_ FDSVQ 96_ VVFTI 101_ CTAVL 106_ ATIAF 111_ AFLLL 116_ PMCQY 121_ LTRPC 126_ SPQNK 131_ ISFGC 136_ CGRFT 141_ AAELL 146_ SFSLS 151_ VMLVL 156_ IWVLT 161_ GHWLL 166_ MDALA 171_ MGLCV 176_ AMIAF 181_ VRLPS 186_ LKVSC 191_ LLLSG 196_ LLIYD 201_ VFWVF 206_ FSAYI 211_ FNSNV 216_ MVKVA 221_ TQPAD 226_ NPLDV 231_ LSRKL 236_ HLGPN 241_ VGRDV 246_ PRLSL 251_ PGKLV 256_ FPSST 261_ GSHFS 266_ MLGIG 271_ DIVMP 276_ GLLLC 281_ FVLRY 286_ DNYKK 291_ QASGD 296_ SCGAP 301_ GPANI 306_ SGRMQ 311_ KVSYF 316_ HCTLI 321_ GYFVG 326_ LLTAT 331_ VASRI 336_ HRAAQ 341_ PALLY 346_ LVPFT 351_ LLPLL 356_ TMAYL 361_ KGDLR 366_ RMWSE 371_ PFHSK 376_SSSSR
1: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971)