Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)
1_MAAAV 6_ AAALA 11_ RLLAA 16_ FLLLA 21_ AQVAC 26_ EYGMV 31_ HVVSQ 36_ AGGPE 41_ GKDYC 46_ ILYNP 51_ QWAHL 56_ PHDLS 61_ KASFL 66_ QLRNW 71_ TASLL 76_ CSAAD 81_ LPARG 86_ FSNQI 91_ PLVAR 96_ GNCTF 101_ YEKVR 106_ LAQGS 111_ GARGL 116_ LIVSR 121_ ERLVP 126_ PGGNK 131_ TQYDE 136_ IGIPV 141_ ALLSY 146_ KDMLD 151_ IFTRF 156_ GRTVR 161_ AALYA 166_ PKEPV 171_ LDYNM 176_ VIIFI 181_ MAVGT 186_ VAIGG 191_ YWAGS 196_ RDVKK 201_ RYMKH 206_ KRDDG 211_ PEKQE 216_ DEAVD 221_ VTPVM 226_ TCVFV 231_ VMCCS 236_ MLVLL 241_ YYFYD 246_ LLVYV 251_ VIGIF 256_ CLASA 261_ TGLYS 266_ CLAPC 271_ VRRLP 276_ FGKCR 281_ IPNNS 286_ LPYFH 291_ KRPQA 296_ RMLLL 301_ ALFCV 306_ AVSVV 311_ WGVFR 316_ NEDQW 321_ AWVLQ 326_ DALGI 331_ AFCLY 336_ MLKTI 341_ RLPTF 346_ KACTL 351_ LLLVL 356_ FLYDI 361_ FFVFI 366_ TPFLT 371_ KSGSS 376_ IMVEV 381_ ATGPS 386_ DSATR 391_ EKLPM 396_ VLKVP 401_ RLNSS 406_ PLALC 411_ DRPFS 416_ LLGFG 421_ DILVP 426_ GLLVA 431_ YCHRF 436_ DIQVQ 441_ SSRVY 446_ FVACT 451_ IAYGV 456_ GLLVT 461_ FVALA 466_ LMQRG 471_ QPALL 476_ YLVPC 481_ TLVTS 486_ CAVAL 491_ WRREL 496_ GVFWT 501_ GSGFA 506_ KVLPP 511_ SPWAP 516_ APADG 521_ PQPPK 526_ DSATP 531_ LSPQP 536_ PSEEP 541_ ATSPW 546_ PAEQS 551_ PKSRT 556_ SEEMG 561_ AGAPM 566_ REPGS 571_ PAESE 576_ GRDQA 581_ QPSPV 586_TQPGA
1: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829951, PubMed:16829952). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852)