Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)
1_MGPQR 6_ RLSPA 11_ GAALL 16_ WGFLL 21_ QLTAA 26_ QEAIL 31_ HASGN 36_ GTTKD 41_ YCMLY 46_ NPYWT 51_ ALPST 56_ LENAT 61_ SISLM 66_ NLTST 71_ PLCNL 76_ SDIPP 81_ VGIKS 86_ KAVVV 91_ PWGSC 96_ HFLEK 101_ ARIAQ 106_ KGGAE 111_ AMLVV 116_ NNSVL 121_ FPPSG 126_ NRSEF 131_ PDVKI 136_ LIAFI 141_ SYKDF 146_ RDMNQ 151_ TLGDN 156_ ITVKM 161_ YSPSW 166_ PNFDY 171_ TMVVI 176_ FVIAV 181_ FTVAL 186_ GGYWS 191_ GLVEL 196_ ENLKA 201_ VTTED 206_ REMRK 211_ KKEEY 216_ LTFSP 221_ LTVVI 226_ FVVIC 231_ CVMMV 236_ LLYFF 241_ YKWLV 246_ YVMIA 251_ IFCIA 256_ SAMSL 261_ YNCLA 266_ ALIHK 271_ IPYGQ 276_ CTIAC 281_ RGKNM 286_ EVRLI 291_ FLSGL 296_ CIAVA 301_ VVWAV 306_ FRNED 311_ RWAWI 316_ LQDIL 321_ GIAFC 326_ LNLIK 331_ TLKLP 336_ NFKSC 341_ VILLG 346_ LLLLY 351_ DVFFV 356_ FITPF 361_ ITKNG 366_ ESIMV 371_ ELAAG 376_ PFGNN 381_ EKLPV 386_ VIRVP 391_ KLIYF 396_ SVMSV 401_ CLMPV 406_ SILGF 411_ GDIIV 416_ PGLLI 421_ AYCRR 426_ FDVQT 431_ GSSYI 436_ YYVSS 441_ TVAYA 446_ IGMIL 451_ TFVVL 456_ VLMKK 461_ GQPAL 466_ LYLVP 471_ CTLIT 476_ ASVVA 481_ WRRKE 486_ MKKFW 491_ KGNSY 496_ QMMDH 501_ LDCAT 506_ NEENP 511_VISGE
1: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829951, PubMed:16829952, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system (By similarity). Plays a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852)