Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase)
1_MDSAL 6_ SDPHN 11_ GSAEA 16_ GGPTN 21_ STTRP 26_ PSTPE 31_ GIALA 36_ YGSLL 41_ LMALL 46_ PIFFG 51_ ALRSV 56_ RCARG 61_ KNASD 66_ MPETI 71_ TSRDA 76_ ARFPI 81_ IASCT 86_ LLGLY 91_ LFFKI 96_ FSQEY 101_ INLLL 106_ SMYFF 111_ VLGIL 116_ ALSHT 121_ ISPFM 126_ NKFFP 131_ ASFPN 136_ RQYQL 141_ LFTQG 146_ SGENK 151_ EEIIN 156_ YEFDT 161_ KDLVC 166_ LGLSS 171_ IVGVW 176_ YLLRK 181_ HWIAN 186_ NLFGL 191_ AFSLN 196_ GVELL 201_ HLNNV 206_ STGCI 211_ LLGGL 216_ FIYDV 221_ FWVFG 226_ TNVMV 231_ TVAKS 236_ FEAPI 241_ KLVFP 246_ QDLLE 251_ KGLEA 256_ NNFAM 261_ LGLGD 266_ VVIPG 271_ IFIAL 276_ LLRFD 281_ ISLKK 286_ NTHTY 291_ FYTSF 296_ AAYIF 301_ GLGLT 306_ IFIMH 311_ IFKHA 316_ QPALL 321_ YLVPA 326_ CIGFP 331_ VLVAL 336_ AKGEV 341_ TEMFS 346_ YEESN 351_ PKDPA 356_ AVTES 361_ KEGTE 366_ ASASK 371_GLEKK
1: Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm (PubMed:12077416). Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:11714810, PubMed:12077416, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity)