Glutamate receptor ionotropic, NMDA 3A (GluN3A) (N-methyl-D-aspartate receptor subtype 3A) (NMDAR3A) (NR3A) (NMDAR-L)
1_MRRLS 6_ LWWLL 11_ SRVCL 16_ LLPPP 21_ CALVL 26_ AGVPS 31_ SSSHP 36_ QPCQI 41_ LKRIG 46_ HAVRV 51_ GAVHL 56_ QPWTT 61_ APRAA 66_ SRAPD 71_ DSRAG 76_ AQRDE 81_ PEPGT 86_ RRSPA 91_ PSPGA 96_ RWLGS 101_ TLHGR 106_ GPPGS 111_ RKPGE 116_ GARAE 121_ ALWPR 126_ DALLF 131_ AVDNL 136_ NRVEG 141_ LLPYN 146_ LSLEV 151_ VMAIE 156_ AGLGD 161_ LPLLP 166_ FSSPS 171_ SPWSS 176_ DPFSF 181_ LQSVC 186_ HTVVV 191_ QGVSA 196_ LLAFP 201_ QSQGE 206_ MMELD 211_ LVSLV 216_ LHIPV 221_ ISIVR 226_ HEFPR 231_ ESQNP 236_ LHLQL 241_ SLENS 246_ LSSDA 251_ DVTVS 256_ ILTMN 261_ NWYNF 266_ SLLLC 271_ QEDWN 276_ ITDFL 281_ LLTQN 286_ NSKFH 291_ LGSII 296_ NITAN 301_ LPSTQ 306_ DLLSF 311_ LQIQL 316_ ESIKN 321_ STPTV 326_ VMFGC 331_ DMESI 336_ RRIFE 341_ ITTQF 346_ GVMPP 351_ ELRWV 356_ LGDSQ 361_ NVEEL 366_ RTEGL 371_ PLGLI 376_ AHGKT 381_ TQSVF 386_ EHYVQ 391_ DAMEL 396_ VARAV 401_ ATATM 406_ IQPEL 411_ ALIPS 416_ TMNCM 421_ EVETT 426_ NLTSG 431_ QYLSR 436_ FLANT 441_ TFRGL 446_ SGSIR 451_ VKGST 456_ IVSSE 461_ NNFFI 466_ WNLQH 471_ DPMGK 476_ PMWTR 481_ LGSWQ 486_ GGKIV 491_ MDYGI 496_ WPEQA 501_ QRHKT 506_ HFQHP 511_ SKLHL 516_ RVVTL 521_ IEHPF 526_ VFTRE 531_ VDDEG 536_ LCPAG 541_ QLCLD 546_ PMTND 551_ SSTLD 556_ SLFSS 561_ LHSSN 566_ DTVPI 571_ KFKKC 576_ CYGYC 581_ IDLLE 586_ KIAED 591_ MNFDF 596_ DLYIV 601_ GDGKY 606_ GAWKN 611_ GHWTG 616_ LVGDL 621_ LRGTA 626_ HMAVT 631_ SFSIN 636_ TARSQ 641_ VIDFT 646_ SPFFS 651_ TSLGI 656_ LVRTR 661_ DTAAP 666_ IGAFM 671_ WPLHW 676_ TMWLG 681_ IFVAL 686_ HITAV 691_ FLTLY 696_ EWKSP 701_ FGLTP 706_ KGRNR 711_ SKVFS 716_ FSSAL 721_ NICYA 726_ LLFGR 731_ TVAIK 736_ PPKCW 741_ TGRFL 746_ MNLWA 751_ IFCMF 756_ CLSTY 761_ TANLA 766_ AVMVG 771_ EKIYE 776_ ELSGI 781_ HDPKL 786_ HHPSQ 791_ GFRFG 796_ TVRES 801_ SAEDY 806_ VRQSF 811_ PEMHE 816_ YMRRY 821_ NVPAT 826_ PDGVE 831_ YLKND 836_ PEKLD 841_ AFIMD 846_ KALLD 851_ YEVSI 856_ DADCK 861_ LLTVG 866_ KPFAI 871_ EGYGI 876_ GLPPN 881_ SPLTA 886_ NISEL 891_ ISQYK 896_ SHGFM 901_ DMLHD 906_ KWYRV 911_ VPCGK 916_ RSFAV 921_ TETLQ 926_ MGIKH 931_ FSGLF 936_ VLLCI 941_ GFGLS 946_ ILTTI 951_ GEHIV 956_ YRLLL 961_ PRIKN 966_ KSKLQ 971_ YWLHT 976_ SQRLH 981_ RAINT 986_ SFIEE 991_ KQQHF 996_ KTKRV 1001_ EKRSN 1006_ VGPRQ 1011_ LTVWN 1016_ TSNLS 1021_ HDNRR 1026_ KYIFS 1031_ DEEGQ 1036_ NQLGI 1041_ RIHQD 1046_ IPLPP 1051_ RRREL 1056_ PALRT 1061_ TNGKA 1066_ DSLNV 1071_ SRNSV 1076_ MQELS 1081_ ELEKQ 1086_ IQVIR 1091_ QELQL 1096_ AVSRK 1101_ TELEE 1106_YQRTS
1: Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+) (By similarity). During the development of neural circuits, participates in the synaptic refinement period, restricting spine maturation and growth (By similarity). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity). Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:38598639). GluN3A subunit also binds D-serine (By similarity). Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity). By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses (By similarity)