Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)
1_MEAPS 6_ GSEPG 11_ GDGAG 16_ DCAHP 21_ DPRAP 26_ GAAAP 31_ SSGPG 36_ PCAAA 41_ RESER 46_ QLRLR 51_ LCVLN 56_ EILGT 61_ ERDYV 66_ GTLRF 71_ LQSAF 76_ LHRIR 81_ QNVAD 86_ SVEKG 91_ LTEEN 96_ VKVLF 101_ SNIED 106_ ILEVH 111_ KDFLA 116_ ALEYC 121_ LHPEP 126_ QSQHE 131_ LGNVF 136_ LKFKD 141_ KFCVY 146_ EEYCS 151_ NHEKA 156_ LRLLV 161_ ELNKI 166_ PTVRA 171_ FLLSC 176_ MLLGG 181_ RKTTD 186_ IPLEG 191_ YLLSP 196_ IQRIC 201_ KYPLL 206_ LKELA 211_ KRTPG 216_ KHPDH 221_ PAVQS 226_ ALQAM 231_ KTVCS 236_ NINET 241_ KRQME 246_ KLEAL 251_ EQLQS 256_ HIEGW 261_ EGSNL 266_ TDICT 271_ QLLLQ 276_ GTLLK 281_ ISAGN 286_ IQERA 291_ FFLFD 296_ NLLVY 301_ CKRKS 306_ RVTGS 311_ KKSTK 316_ RTKSI 321_ NGSLY 326_ IFRGR 331_ INTEV 336_ MEVEN 341_ VEDGT 346_ ADYHS 351_ NGYTV 356_ TNGWK 361_ IHNTA 366_ KNKWF 371_ VCMAK 376_ TAEEK 381_ QKWLD 386_ AIIRE 391_ REQRE 396_ SLKLG 401_ MERDA 406_ YVMIA 411_ EKGEK 416_ LYHMM 421_ MNKKV 426_ NLIKD 431_ RRRKL 436_ STVPK 441_ CFLGN 446_ EFVAW 451_ LLEIG 456_ EISKT 461_ EEGVN 466_ LGQAL 471_ LENGI 476_ IHHVS 481_ DKHQF 486_ KNEQV 491_ MYRFR 496_ YDDGT 501_ YKARS 506_ ELEDI 511_ MSKGV 516_ RLYCR 521_ LHSLY 526_ TPVIK 531_ DRDYH 536_ LKTYK 541_ SVLPG 546_ SKLVD 551_ WLLAQ 556_ GDCQT 561_ REEAV 566_ ALGVG 571_ LCNNG 576_ FMHHV 581_ LEKSE 586_ FRDES 591_ QYFRF 596_ HADEE 601_ MEGTS 606_ SKNKQ 611_ LRNDF 616_ KLVEN 621_ ILAKR 626_ LLILP 631_ QEEDY 636_ GFDIE 641_ EKNKA 646_ VVVKS 651_ VQRGS 656_ LAEVA 661_ GLQVG 666_ RKIYS 671_ INEDL 676_ VFLRP 681_ FSEVE 686_ SILNQ 691_ SFCSR 696_ RPLRL 701_ LVATK 706_ AKEII 711_ KIPDQ 716_ PDTLC 721_ FQIRG 726_ AAPPY 731_ VYAVG 736_ RGSEA 741_ MAAGL 746_ CAGQC 751_ ILKVN 756_ GSNVM 761_ NDGAP 766_ EVLEH 771_ FQAFR 776_ SRREE 781_ ALGLY 786_ QWIYH 791_ THEDA 796_ QEARA 801_ SQEAS 806_ TEDPS 811_ GEQAQ 816_ EEDQA 821_ DSAFP 826_ LLSLG 831_ PRLSL 836_ CEDSP 841_ MVTLT 846_ VDNVH 851_ LEHGV 856_ VYEYV 861_ STAGV 866_ RCHVL 871_ EKIVE 876_ PRGCF 881_ GLTAK 886_ ILEAF 891_ AANDS 896_ VFVEN 901_ CRRLM 906_ ALSSA 911_ IVTMP 916_ HFEFR 921_ NICDT 926_ KLESI 931_ GQRIA 936_ CYQEF 941_ AAQLK 946_ SRVSP 951_ PFKQA 956_ PLEPH 961_ PLCGL 966_ DFCPT 971_ NCHIN 976_ LMEVS 981_ YPKTT 986_ PSVGR 991_ SFSIR 996_ FGRKP 1001_ SLIGL 1006_ DPEQG 1011_ HLNPM 1016_ SYTQH 1021_ CITTM 1026_ AAPSW 1031_ KCLPA 1036_ AEGDP 1041_ QGQGL 1046_ HDGSF 1051_ GPASG 1056_ TLGQE 1061_ DRGLS 1066_ FLLKQ 1071_ EDREI 1076_ QDAYL 1081_ QLFTK 1086_ LDVAL 1091_ KEMKQ 1096_ YVTQI 1101_ NRLLS 1106_ TITEP 1111_ TSGGS 1116_ CDASL 1121_ AEEAS 1126_ SLPLV 1131_ SEESE 1136_ MDRSD 1141_ HGGIK 1146_ KVCFK 1151_ VAEED 1156_ QEDSG 1161_ HDTMS 1166_ YRDSY 1171_ SECNS 1176_ NRDSV 1181_ LSYTS 1186_ VRSNS 1191_ SYLGS 1196_ DEMGS 1201_ GDELP 1206_ CDMRI 1211_ PSDKQ 1216_ DKLHG 1221_ CLEHL 1226_ FNQVD 1231_ SINAL 1236_ LKGPV 1241_ MSRAF 1246_ EETKH 1251_ FPMNH 1256_ SLQEF 1261_ KQKEE 1266_ CTIRG 1271_ RSLIQ 1276_ ISIQE 1281_ DPWNL 1286_ PNSIK 1291_ TLVDN 1296_ IQRYV 1301_ EDGKN 1306_ QLLLA 1311_ LLKCT 1316_ DTELQ 1321_ LRRDA 1326_ IFCQA 1331_ LVAAV 1336_ CTFSK 1341_ QLLAA 1346_ LGYRY 1351_ NNNGE 1356_ YEESS 1361_ RDASR 1366_ KWLEQ 1371_ VAATG 1376_ VLLHC 1381_ QSLLS 1386_ PATVK 1391_ EERTM 1396_ LEDIW 1401_ VTLSE 1406_ LDNVT 1411_ FSFKQ 1416_ LDENY 1421_ VANTN 1426_ VFYHI 1431_ EGSRQ 1436_ ALKVI 1441_ FYLDS 1446_ YHFSK 1451_ LPSRL 1456_ EGGAS 1461_ LRLHT 1466_ ALFTK 1471_ VLENV 1476_ EGLPS 1481_ PGSQA 1486_ AEDLQ 1491_ QDINA 1496_ QSLEK 1501_ VQQYY 1506_ RKLRA 1511_ FYLER 1516_ SNLPT 1521_ DASTT 1526_ AVKID 1531_ QLIRP 1536_ INALD 1541_ ELCRL 1546_ MKSFV 1551_ HPKPG 1556_ AAGSV 1561_ GAGLI 1566_ PISSE 1571_ LCYRL 1576_ GACQM 1581_ VMCGT 1586_ GMQRS 1591_ TLSVS 1596_ LEQAA 1601_ ILARS 1606_ HGLLP 1611_ KCIMQ 1616_ ATDIM 1621_ RKQGP 1626_ RVEIL 1631_ AKNLR 1636_ VKDQM 1641_ PQGAP 1646_ RLYRL 1651_CQPPV
1: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils