Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)
1_MCTVV 6_ DPRIV 11_ RRYLL 16_ RRQLG 21_ QGAYG 26_ IVWKA 31_ VDRRT 36_ GEVVA 41_ IKKIF 46_ DAFRD 51_ KTDAQ 56_ RTFRE 61_ ITLLQ 66_ EFGDH 71_ PNIIS 76_ LLDVI 81_ RAEND 86_ RDIYL 91_ VFEFM 96_ DTDLN 101_ AVIRK 106_ GGLLQ 111_ DVHVR 116_ SIFYQ 121_ LLRAT 126_ RFLHS 131_ GHVVH 136_ RDQKP 141_ SNVLL 146_ DANCT 151_ VKLCD 156_ FGLAR 161_ SLGDL 166_ PEGPE 171_ DQAVT 176_ EYVAT 181_ RWYRA 186_ PEVLL 191_ SSHRY 196_ TLGVD 201_ MWSLG 206_ CILGE 211_ MLRGR 216_ PLFPG 221_ TSTLH 226_ QLELI 231_ LETIP 236_ PPSEE 241_ DLLAL 246_ GSGCR 251_ ASVLH 256_ QLGSR 261_ PRQTL 266_ DALLP 271_ PDTSP 276_ EALDL 281_ LRRLL 286_ VFAPD 291_ KRLSA 296_ TQALQ 301_ HPYVQ 306_ RFHCP 311_ SDEWA 316_ READV 321_ RPRAH 326_ EGVQL 331_ SVPEY 336_ RSRVY 341_ QMILE 346_ CGGSS 351_ GTSRE 356_ KGPEG 361_ VSPSQ 366_ AHLHK 371_ PRADP 376_ QLPSR 381_ TPVQG 386_ PRPRP 391_ QSSPG 396_ HDPAE 401_ HESPR 406_ AAKNV 411_ PRQNS 416_ APLLQ 421_ TALLG 426_ NGERP 431_ PGAKE 436_ APPLT 441_ LSLVK 446_ PSGRG 451_ AAPSL 456_ TSQAA 461_ AQVAN 466_ QALIR 471_ GDWNR 476_ GGGVR 481_ VASVQ 486_ QVPPR 491_ LPPEA 496_ RPGRR 501_ MFSTS 506_ ALQGA 511_ QGGAR 516_ ALLGG 521_ YSQAY 526_ GTVCH 531_ SALGH 536_LPLLE
1: Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (PubMed:20733054, PubMed:21847093, PubMed:22948227, PubMed:24618899, PubMed:29021280). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227). Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899). Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093). Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA (PubMed:20733054). Regulates DA transporter (DAT) activity and protein expression via activation of RhoA (PubMed:28842414). In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression (PubMed:26595526). Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP (PubMed:11875070, PubMed:16484222, PubMed:19166846, PubMed:20638370). During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity (PubMed:21190936)