Protein bicaudal D homolog 2 (Bic-D 2)
1_MSAPS 6_ EEEEY 11_ ARLVM 16_ EAQPE 21_ WLRAE 26_ VKRLS 31_ HELAE 36_ TTREK 41_ IQAAE 46_ YGLAV 51_ LEEKH 56_ QLKLQ 61_ FEELE 66_ VDYEA 71_ IRSEM 76_ EQLKE 81_ AFGQA 86_ HTNHK 91_ KVAAD 96_ GESRE 101_ ESLIQ 106_ ESASK 111_ EQYYV 116_ RKVLE 121_ LQTEL 126_ KQLRN 131_ VLTNT 136_ QSENE 141_ RLASV 146_ AQELK 151_ EINQN 156_ VEIQR 161_ GRLRD 166_ DIKEY 171_ KFREA 176_ RLLQD 181_ YSELE 186_ EENIS 191_ LQKQV 196_ SVLRQ 201_ NQVEF 206_ EGLKH 211_ EIKRL 216_ EEETE 221_ YLNSQ 226_ LEDAI 231_ RLKEI 236_ SERQL 241_ EEALE 246_ TLKTE 251_ REQKN 256_ SLRKE 261_ LSHYM 266_ SINDS 271_ FYTSH 276_ LHVSL 281_ DGLKF 286_ SDDAA 291_ EPNND 296_ AEALV 301_ NGFEH 306_ GGLAK 311_ LPLDN 316_ KTSTP 321_ KKEGL 326_ APPSP 331_ SLVSD 336_ LLSEL 341_ NISEI 346_ QKLKQ 351_ QLMQM 356_ EREKA 361_ GLLAT 366_ LQDTQ 371_ KQLEH 376_ TRGSL 381_ SEQQE 386_ KVTRL 391_ TENLS 396_ ALRRL 401_ QASKE 406_ RQTAL 411_ DNEKD 416_ RDSHE 421_ DGDYY 426_ EVDIN 431_ GPEIL 436_ ACKYH 441_ VAVAE 446_ AGELR 451_ EQLKA 456_ LRSTH 461_ EAREA 466_ QHAEE 471_ KGRYE 476_ AEGQA 481_ LTEKV 486_ SLLEK 491_ ASRQD 496_ RELLA 501_ RLEKE 506_ LKKVS 511_ DVAGE 516_ TQGSL 521_ SVAQD 526_ ELVTF 531_ SEELA 536_ NLYHH 541_ VCMCN 546_ NETPN 551_ RVMLD 556_ YYREG 561_ QGGAG 566_ RTSPG 571_ GRTSP 576_ EARGR 581_ RSPIL 586_ LPKGL 591_ LAPEA 596_ GRADG 601_ GTGDS 606_ SPSPG 611_ SSLPS 616_ PLSDP 621_ RREPM 626_ NIYNL 631_ IAIIR 636_ DQIKH 641_ LQAAV 646_ DRTTE 651_ LSRQR 656_ IASQE 661_ LGPAV 666_ DKDKE 671_ ALMEE 676_ ILKLK 681_ SLLST 686_ KREQI 691_ TTLRT 696_ VLKAN 701_ KQTAE 706_ VALAN 711_ LKSKY 716_ ENEKA 721_ MVTET 726_ MMKLR 731_ NELKA 736_ LKEDA 741_ ATFSS 746_ LRAMF 751_ ATRCD 756_ EYITQ 761_ LDEMQ 766_ RQLAA 771_ AEDEK 776_ KTLNS 781_ LLRMA 786_ IQQKL 791_ ALTQR 796_ LELLE 801_ LDHEQ 806_ TRRGR 811_ AKAAP 816_KTKPA
1: Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25814576). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex (PubMed:25962623). Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis (By similarity)