Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8)
1_MSVLG 6_ EYERH 11_ CDSIN 16_ SDFGS 21_ ESGGC 26_ GDSSP 31_ GPSAS 36_ QGPRA 41_ GGGAA 46_ EQEEL 51_ HYIPI 56_ RVLGR 61_ GAFGE 66_ ATLYR 71_ RTEDD 76_ SLVVW 81_ KEVDL 86_ TRLSE 91_ KERRD 96_ ALNEI 101_ VILAL 106_ LQHDN 111_ IIAYY 116_ NHFMD 121_ NTTLL 126_ IELEY 131_ CNGGN 136_ LYDKI 141_ LRQKD 146_ KLFEE 151_ EMVVW 156_ YLFQI 161_ VSAVS 166_ CIHKA 171_ GILHR 176_ DIKTL 181_ NIFLT 186_ KANLI 191_ KLGDY 196_ GLAKK 201_ LNSEY 206_ SMAET 211_ LVGTP 216_ YYMSP 221_ ELCQG 226_ VKYNF 231_ KSDIW 236_ AVGCV 241_ IFELL 246_ TLKRT 251_ FDATN 256_ PLNLC 261_ VKIVQ 266_ GIRAM 271_ EVDSS 276_ QYSLE 281_ LIQMV 286_ HSCLD 291_ QDPEQ 296_ RPTAD 301_ ELLDR 306_ PLLRK 311_ RRREM 316_ EEKVT 321_ LLNAP 326_ TKRPR 331_ SSTVT 336_ EAPIA 341_ VVTSR 346_ TSEVY 351_ VWGGG 356_ KSTPQ 361_ KLDVI 366_ KSGCS 371_ ARQVC 376_ AGNTH 381_ FAVVT 386_ VEKEL 391_ YTWVN 396_ MQGGT 401_ KLHGQ 406_ LGHGD 411_ KASYR 416_ QPKHV 421_ EKLQG 426_ KAIRQ 431_ VSCGD 436_ DFTVC 441_ VTDEG 446_ QLYAF 451_ GSDYY 456_ GCMGV 461_ DKVAG 466_ PEVLE 471_ PMQLN 476_ FFLSN 481_ PVEQV 486_ SCGDN 491_ HVVVL 496_ TRNKE 501_ VYSWG 506_ CGEYG 511_ RLGLD 516_ SEEDY 521_ YTPQK 526_ VDVPK 531_ ALIIV 536_ AVQCG 541_ CDGTF 546_ LLTQS 551_ GKVLA 556_ CGLNE 561_ FNKLG 566_ LNQCM 571_ SGIIN 576_ HEAYH 581_ EVPYT 586_ TSFTL 591_ AKQLS 596_ FYKIR 601_ TIAPG 606_ KTHTA 611_ AIDER 616_ GRLLT 621_ FGCNK 626_ CGQLG 631_ VGNYK 636_ KRLGI 641_ NLLGG 646_ PLGGK 651_ QVIRV 656_ SCGDE 661_ FTIAA 666_ TDDNH 671_ IFAWG 676_ NGGNG 681_ RLAMT 686_ PTERP 691_ HGSDI 696_ CTSWP 701_ RPIFG 706_ SLHHV 711_ PDLSC 716_ RGWHT 721_ ILIVE 726_ KVLNS 731_ KTIRS 736_ NSSGL 741_ SIGTV 746_ FQSSS 751_ PGGGG 756_ GGGGG 761_ EEEDS 766_ QQESE 771_ TPDPS 776_ GGFRG 781_ TMEAD 786_ RGMEG 791_ LISPT 796_ EAMGN 801_ SNGAS 806_ SSCPG 811_ WLRKE 816_ LENAE 821_ FIPMP 826_ DSPSP 831_ LSAAF 836_ SESEK 841_ DTLPY 846_ EELQG 851_ LKVAS 856_ EAPLE 861_ HKPQV 866_ EASSP 871_ RLNPA 876_ VTCAG 881_ KGTPL 886_ TPPAC 891_ ACSSL 896_ QVEVE 901_ RLQGL 906_ VLKCL 911_ AEQQK 916_ LQQEN 921_ LQIFT 926_ QLQKL 931_ NKKLE 936_ GGQQV 941_ GMHSK 946_ GTQTA 951_ KEEME 956_ MDPKP 961_ DLDSD 966_ SWCLL 971_GTDSC
1: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158)